KCTD9(8p21.2), BTBD27,

https://www.ncbi.nlm.nih.gov/gene/54793

1. NM_017634.4 → NP_060104.2  BTB/POZ domain-containing protein KCTD9
   See identical proteins and their annotated locations for NP_060104.2
   
   

   Conserved Domains (3) summary

   COG1357
   Location:168 → 378

   YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]

   
   

   pfam11834
   Location:2 → 64

   KHA; KHA, dimerisation domain of potassium ion channelKHA is the tetramerisation domain of eukaryotic voltage-dependent potassium ion-channel proteins. In plants the domain lies at the C-terminus whereas in many chordates it lies at the N-terminus.

   cl02518
   Location:91 → 181

   BTB; BTB/POZ domain

1. KCTD9 contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. Chen T, et al. Clin Immunol, 2013 Mar. PMID 23376586
2. [Increased expression of KCTD9, a novel potassium channel related gene, correlates with disease severity in patients with viral hepatitis B]. Zhou YY, et al. Zhonghua Gan Zang Bing Za Zhi, 2008 Nov. PMID 19032868
3. Structural Insights into KCTD Protein Assembly and Cullin3 Recognition. Ji AX, et al. J Mol Biol, 2016 Jan 16. PMID 26334369 AbstractCullin3 (Cul3)-based ubiquitin E3 ligase complexes catalyze the transfer of ubiquitin from an E2 enzyme to target substrate proteins. In these assemblies, the C-terminal region of Cul3 binds Rbx1/E2-ubiquitin, while the N-terminal region interacts with various BTB (bric-à-brac, tramtrack, broad complex) domain proteins that serve as substrate adaptors. Previous crystal structures of the homodimeric BTB proteins KLHL3, KLHL11 and SPOP in complex with the N-terminal domain of Cul3 revealed the features required for Cul3 recognition in these proteins. A second class of BTB-domain-containing proteins, the KCTD proteins, is also Cul3 substrate adaptors, but these do not share many of the previously identified determinants for Cul3 binding. We report the pentameric crystal structures of the KCTD1 and KCTD9 BTB domains and identify plasticity in the KCTD1 rings. We find that the KCTD proteins 5, 6, 9 and 17 bind to Cul3 with high affinity, while the KCTD proteins 1 and 16 do not have detectable binding. Finally, we confirm the 5:5 assembly of KCTD9/Cul3 complexes by cryo-electron microscopy and provide a molecular rationale for BTB-mediated Cul3 binding specificity in the KCTD family.
   
4. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. Yu Y, et al. Genome Res, 2001 Aug. PMID 11483580, Free PMC Article
5. Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation. Scott DC, et al. Cell, 2016 Aug 25. PMID 27565346, Free PMC Article

See all (20) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. The authors find that the KCTD proteins 5, 6, 9 and 17 bind to Cul3 with high affinity, while the KCTD proteins 1 and 16 do not have detectable binding.
2. These results suggest the involvement of KCTD9 in NK cell activation and provide additional insight into a potential therapeutic target for molecular manipulation for hepatitis B virus-induced acute-on-chronic liver failure patients
3. The increased expression of potassium channel gene KCTD9 correlates with disease severity in patients with viral hepatitis B.