KCTD11 (17p13.1), KCASH1, REN, REN/KCRD11, C17orf36, tuumorisuppressorigeeni

KCTD11 (17p13.1)

https://www.ncbi.nlm.nih.gov/gene/147040

Also known as

REN; KCASH1; C17orf36; REN/KCTD11

Preferred Names

BTB/POZ domain-containing protein KCTD11

Names

RING-type E3 ubiquitin transferase subunit KCTD11

potassium channel tetramerization domain-containing protein 11

Retinoic acid, EGF, NGF induced gene protein

 https://www.ncbi.nlm.nih.gov/protein/NP_001002914.1

ORIGIN      
        1 mlgamfragt pmppnlnsqg gghyfidrdg kafrhilnfl rlgrldlprg ygetallrae
       61 adfyqirpll dalreleasq gtpaptaall hadvdvsprl vhfsarrgph hyelssvqvd
      121 tfranlfctd seclgalrar fgvasgdrae gsphfhlewa prpvelpeve ygrlglqplw
      181 tggpgerrev vgtpsfleev lrvalehgfr ldsvfpdped llnsrslrfv rh
//

Related articles in PubMed

1. KCTD11 tumor suppressor gene expression is reduced in prostate adenocarcinoma. Zazzeroni F, et al. Biomed Res Int, 2014. PMID 25045667, Free PMC Article
2. Molecular organization of the cullin E3 ligase adaptor KCTD11. Correale S, et al. Biochimie, 2011 Apr. PMID 21237243
3. The tumor suppressor gene KCTD11REN is regulated by Sp1 and methylation and its expression is reduced in tumors. Mancarelli MM, et al. Mol Cancer, 2010 Jun 30. PMID 20591193, Free PMC Article
4. Cullin 3 Recognition Is Not a Universal Property among KCTD Proteins. Smaldone G, et al. PLoS One, 2015. PMID 25974686, Free PMC Article
5. REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma. Di Marcotullio L, et al. Proc Natl Acad Sci U S A, 2004 Jul 20. PMID 15249678, Free PMC Article

See all (14) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. Our study demonstrates and supports that KCTD11, as well as negatively regulated downstream effectors belonging to Hh signaling, plays a role in prostate cancer pathogenesis.
2. the protein is expressed in two alternative variants: a short previously characterized form (sKCTD11) composed by 232 amino acids and a longer variant (lKCTD11) which contains an N-terminal extension of 39 residues.
3. findings identify KCTD11 as a widely down-regulated gene in human cancers, and provide a basis to understand how its expression might be deregulated in tumor cells
4. Results identify REN(KCTD11) as a suppressor of Hedgehog signaling and suggest that its inactivation might lead to a deregulation of the tumor-promoting Hedgehog pathway in medulloblastoma.