KCTD8(4p13). Merkitys aivojenksvulle. Tupakointi on haittatekijä.

https://www.ncbi.nlm.nih.gov/gene/386617

KCTD8

Official Full Name

potassium channel tetramerization domain containing 8provided by HGNC

Expression

Biased expression in brain (RPKM 3.7), thyroid (RPKM 1.4) and 7 other tissues See more

Orthologs

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Preferred Names

BTB/POZ domain-containing protein KCTD8

Names

potassium channel tetramerisation domain containing 8

Related articles in PubMed

1. KCTD8 gene and brain growth in adverse intrauterine environment: a genome-wide association study. Paus T, et al. Cereb Cortex, 2012 Nov. PMID 22156575, Free PMC Article
2. Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis. Faryna M, et al. FASEB J, 2012 Dec. PMID 22930747
3. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624, Free PMC Article

See all (8) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.
2. KCTD8 might modulate adverse effects of smoking during pregnancy on brain development via apoptosis triggered by low intracellular levels of potassium, possibly reducing the number of progenitor cells

Cereb Cortex. 2012 Nov;22(11):2634-42. doi: 10.1093/cercor/bhr350. Epub 2011 Dec 9.

KCTD8 gene and brain growth in adverse intrauterine environment: a genome-wide association study.

Paus T¹, Bernard M, Chakravarty MM, Davey Smith G, Gillis J, Lourdusamy A, Melka MG, Leonard G, Pavlidis P, Perron M, Pike GB, Richer L, Schumann G, Timpson N, Toro R, Veillette S, Pausova Z. Abstract

The most dramatic growth of the human brain occurs in utero and during the first 2 years of postnatal life. Genesis of the cerebral cortex involves cell proliferation, migration, and apoptosis, all of which may be influenced by prenatal environment. Here, we show that variation in KCTD8 (potassium channel tetramerization domain 8) is associated with brain size in female adolescents (rs716890, P = 5.40 × 10(-09)). Furthermore, we found that the KCTD8 locus interacts with prenatal exposure to maternal cigarette smoking vis-à-vis cortical area and cortical folding: In exposed girls only, the KCTD8 locus explains up to 21% of variance. Using head circumference as a proxy of brain size at 7 years of age, we have replicated this gene-environment interaction in an independent sample. We speculate that KCTD8 might modulate adverse effects of smoking during pregnancy on brain development via apoptosis triggered by low intracellular levels of potassium, possibly reducing the number of progenitor cells.

PMID:

22156575

PMCID:

PMC3464418

DOI:

10.1093/cercor/bhr350