KCTD3 (1q41), NY-REN-45.

https://www.ncbi.nlm.nih.gov/gene/51133

Official Symbol

KCTD3

Official Full Name

potassium channel tetramerization domain containing 3provided by HGNC

Also known as

NY-REN-45

Summary

This gene encodes a member of the potassium channel tetramerization-domain containing (KCTD) protein family. Members of this protein family regulate the biophysical characteristics of ion channels. In mouse, this protein interacts with hyperpolarization-activated cyclic nucleotide-gated channel complex 3 and enhances its cell surface expression and current density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Expression

Ubiquitous expression in adrenal (RPKM 47.4), small intestine (RPKM 24.0) and 25 other tissues See more

Preferred Names

BTB/POZ domain-containing protein KCTD3

Names

NY-REN-45 antigen

potassium channel tetramerisation domain containing 3

renal carcinoma antigen NY-REN-45

1. NM_016121.5 → NP_057205.2  BTB/POZ domain-containing protein KCTD3 isoform 1
   
   

   Conserved Domains (1) summary

   pfam02214
   Location:20 → 105

   BTB_2; BTB/POZ domain

   

   BTB/POZ domain

   In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. (In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerisation of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha).

ORIGIN      
        1 magghcgsfp aaaagsgeiv qlnvggtrfs tsrqtlmwip dsffssllsg ristlrdetg
       61 aifidrdpaa fapilnflrt keldlrgvsi nvlrheaefy gitplvrrll lceelerssc
      121 gsvlfhgylp ppgipsrkin ntvrsadsrn glnstegear gngtqpvlsg tgeetvrlgf
      181 pvdprkvliv aghhnwivaa yahfavcyri kessgwqqvf tspyldwtie rvalnakvvg
      241 gphgdkdkmv avasessiil wsvqdggsgs eigvfslgvp vdalffignq lvatshtgkv
      301 gvwnavtqhw qvqdvvpits ydtagsflll gcnngsiyyi dmqkfplrmk dndllvtely
      361 hdpsndaita lsvyltpkts vsgnwieiay gtssgavrvi vqhpetvgsg pqlfqtftvh
      421 rspvtkimls ekhlvsvcad nnhvrtwtvt rfrgmistqp gstplasfki lsleeteshg
      481 syssgndigp fgerddqqvf iqkvvpitnk lfvrlsstgk riceiqavdc ttissftvre
      541 cegssrmgsr prrylftght ngsiqmwdlt tamdmvnkse dkdvggptee ellklldqcd
      601 lstsrcatpn ispatsvvqh shlresnssl qlqhhdtthe aatygsmrpy respllarar
      661 rtesfhsyrd fqtinlnrnv eravpengnl gpiqaevkga tgecniserk spgveikslr
      721 eldsglevhk iaegfseskk rssedenenk iefrkkggfe gggflgrkkv pylasspsts
      781 dggtdspgta spsptkttps prhkksdssg qeysl
//

  Region          20..105
                     /region_name="BTB_2"
                     /note="BTB/POZ domain; pfam02214"
                     /db_xref="CDD:308049"
     Region          174..218
                     /region_name="WD 1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y597.2)"
     Region          224..263
                     /region_name="WD 2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y597.2)"
     Region          270..305
                     /region_name="WD 3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y597.2)"
     Region          310..342
                     /region_name="WD 4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y597.2)"
     Region          354..404
                     /region_name="WD 5"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y597.2)"
     Region          412..449
                     /region_name="WD 6"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y597.2)"
     Region          457..504
                     /region_name="WD 7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y597.2)"
     Region          510..569
                     /region_name="WD 8"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y597.2)"
     Region          512..815
                     /region_name="Interaction with HCN3.
                     {ECO:0000250|UniProtKB:Q8BFX3}"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y597.2)"
     Site            604
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {E