Suomalainen sirtuiinikatsaus 2014

(Katsaus näyttää olevan maksullinen ja se on hankittavissa allaolevasta lähteestä. Tiivistelmä ja sisälysluettelo on kuitenkin tarjolla)

Research and Clinical Interventions

2014, Pages 323-332

Chapter 27 - Inflammaging Signaling in Health Span and Life Span Regulation: Next Generation Targets for Longevity

Author links open overlay panelAnteroSalminen¹³AnuKauppinen²KaiKaarniranta²⁴

https://doi.org/10.1016/B978-0-12-397803-5.00027-7Get rights and content

Abstract

The aging process is associated with a low-grade local and systemic inflammation, a condition called inflammaging. The major molecular hallmarks of the aging process include a decline in the autophagic cellular clearing capacity and an increase in NF-κB signaling, a key activator of inflammation. Interestingly, longevity-promoting proteins, e.g. AMPK, SIRT1, and FOXO, are inducers of autophagy and suppressors of NF-κB signaling. These longevity factors also regulate the dietary restriction-induced increase in health span and life span, and thus they are promising drug targets for anti-aging medicine. We will briefly review current knowledge about the signaling network controlling the aging process and evaluate drug discovery approaches to developing anti-aging medications.

Keywords

aging

autophagy

inflammation

life span

longevity

AMPK

NF-κB

SIRT1

Outline

1. Abstract
2. Keywords
3. Acknowledgments
4. Introduction
5. Inflammaging
6. Signaling Network Controlling the Aging Process
   • Insulin/IGF-I-FOXO Pathway
   • AMP-Activated Protein Kinase Signaling
   • Sirtuin Signaling
   • Nuclear Factor-Kappa-B Signaling
7. Dietary Restriction and Extension of Life Span
8. Potential Targets for Anti-Aging Medicine
   • Activation of Autophagy
     • AMP-Activated Protein Kinase Activators
     • SIRT1 Activators
     • mTOR Inhibitors
     • Other Factors
   • Suppression of Local and Systemic Inflammation
     • The Senescence-Associated Secretory Phenotype
     • Inhibition of Nuclear Factor-Kappa-B Signaling and Inflammation
9. Magic Bullets Without Potency
   • Oxidative Stress and Antioxidants
   • Hormone Replacement Therapies
10. Conclusions
11. References