Snail, Slug ja Smad-interaktioprotein1 metastaattisessa ovariaali ja rintasyövässä taudin aggressiivisuudessa (2005). SNAIL perhe 2022 .

 2005

 https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.20946

 2021  ( SNAI1 polymorfismin osuus )

https://www.sciencedirect.com/science/article/abs/pii/S2452014421002648

Volume 24, September 2021, 101279

The effects of SNAI1 rs6125849 gene polymorphism on metastasis and survival in colorectal cancer: Preliminary results from Turkish subjects

Author links open overlay panel

, , , , , ,

https://doi.org/10.1016/j.genrep.2021.101279

Highlights

•SNAI1 involves in many carcinogenic processes and has been considered as a new therapeutic target.

• Since SNAI1 is crucial in carcinogenesis, the effects of SNAI1 gene variations on oncogenic processes have become important in recent years.

• In the present study, we investigated the effects of SNAI1 rs6125849 G>A variation on several features of colorectal cancer (CRC).

• According to our results, rs6125849 variation might have an effect on metastasis and patients survival but not CRC risk and primary tumor location.

• Further in vitro and in vivo studies are necessary to validate our results and understand the function of rs6125849 polymorphism.

• 2022         (SNAI sinkkisormiproteiiniperheen jäsenistä . Onko näistä jotain löytöä  mihin perustaa  syöpälääkitystä?)
  

ORIGINAL RESEARCH article

Front. Cell Dev. Biol., 08 July 2022
Sec. Signaling
Volume 10 - 2022 | https://doi.org/10.3389/fcell.2022.906885

This article is part of the Research Topic

TGF-β and BMP Signaling in Cancer

View all 12 Articles

Analysis of the Effect of SNAI Family in Breast Cancer and Immune Cell

We comprehensively analyzed the roles of SNAIs in cancer. We used Oncomine and TCGA data to analyze pan-cancer SNAI transcript levels. By analyzing UALCAN data, we found correlations between SNAI transcript levels and breast cancer patient characteristics. Kaplan–Meier plotter analysis revealed that SNAI1 and SNAI2 have a bad prognosis, whereas SNAI3 is the opposite. Analysis using the cBio Cancer Genomics Portal revealed alterations in SNAIs in breast cancer subtypes.

 The results showed that SNAI protein levels were correlated with the expression of several immunomodulators and chemokines. Through analysis of PharmacoDB data, we identified antitumor drugs related to SNAI family members and analyzed their IC50 effects on various breast cancer cell lines. In summary, our study revealed that SNAI family members regulate different immune cells infiltrations by gene copy number, mutation, methylation, and expression level. SNAI3 and SNIA1/2 have opposite regulatory effects. They all play a key role in tumor development and immune cell infiltration, and can provide a potential target for drug therapy.

 (Huom: kudos-hypoxia-tekijän  osuuden  heijastus tähän  SNAI-proteiinien  säätymiseen) 

SNAI3 (SMUC, ZNF293) tekee interaktion SMAD 2 ja SMAD 4 proteiinien kannsa ja nämä taas verkostoituvat HIF1A ja   histoiasetylaasien HDAcs suuntaan. 

https://string-db.org/cgi/network?taskId=b6WUo05jUSr1&sessionId=bbL7sWYOUvpk

Gene Families for SNAI3 Gene

HGNC:

• Zinc fingers C2H2-type
• SNAG transcriptional repressors

Human Protein Atlas (HPA):

• Predicted intracellular proteins
• Transcription factors

Protein Domains for SNAI3 Gene

InterPro:

• Znf_C2H2_type
• Znf_C2H2_sf
• Cu_oxidase_Cu_BS

Blocks:

• C2H2-type zinc finger signature

SNAI3_HUMAN :

Domain:

• Binds E-box via C2H2-type zinc finger domain.

Family:

• Belongs to the snail C2H2-type zinc-finger protein family.

Molecular function for SNAI3 Gene according to UniProtKB/Swiss-Prot

Function:

• Seems to inhibit myoblast differentiation.
  Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes.
  Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity). SNAI3_HUMAN,Q3KNW1