71 results
Quantifying Argonaute 2 (Ago2) expression to stratify breast cancer.
BMC Cancer. 2019 Jul 19;19(1):712. doi: 10.1186/s12885-019-5884-x.
PMID: 31324173
Free PMC article.
However Ago2 expression and localisation in breast cancer remains undetermined. ...CONCLUSIONS: Quantification of Ago2 improves the stratification of breast cancer and suggests a differential role for Ago2 in breast cance …
The CXCR4-Dependent LASP1-Ago2 Interaction in Triple-Negative Breast Cancer.
Cancers (Basel). 2020 Aug 29;12(9):2455. doi: 10.3390/cancers12092455.
PMID: 32872485
Free PMC article.
The CXCR4-LASP1 axis is an emerging target in the field of breast cancer
metastasis. C-X-C chemokine receptor type 4 (CXCR4) mediates directed
cell migration when activated by its cognate ligand CXCL12. ...Our
previous proteomics work had revealed several components …
Treatment of breast cancer with autophagy inhibitory microRNAs carried by AGO2-conjugated nanoparticles.
J Nanobiotechnology. 2020 Apr 28;18(1):65. doi: 10.1186/s12951-020-00615-4.
PMID: 32345308
Free PMC article.
These functionalized nanoparticles selectively delivered an effective amount of the microRNA into HER2-positive breast cancer cell lines in vitro and in a xenograft nude mice model of breast cancer in vivo, and successfully blocked autophagy. ...Theref …
Presence of anti-TIF-1gamma, anti-Ro52, anti-SSA/Ro60 and anti-Su/Ago2 antibodies in breast cancer: a cross-sectional study.
Immunopharmacol Immunotoxicol. 2021 Jun;43(3):328-333. doi: 10.1080/08923973.2021.1910833. Epub 2021 Apr 20.
PMID: 33876712
Clinical Trial.
As a whole, 14.47% (22/152) of breast cancer
patients showed autoantibodies associated with SARD. ...CONCLUSIONS:
Autoantibodies to TIF-1gamma were found in two patients with breast cancer without dermatomyositis (DM). More common specificities were au …
MiRNAs Overexpression and Their Role in Breast Cancer: Implications for Cancer Therapeutics.
Curr Drug Targets. 2023;24(6):484-508. doi: 10.2174/1389450124666230329123409.
PMID: 36999414
Review.
This review focuses on the role and mechanisms of miRNAs in different stages of breast cancer progression, including breast cancer stem cell formation, breast cancer initiation, invasion, and metastasis as well as angiogenesis. ...Althoug …
RNA interference: Promising approach for breast cancer diagnosis and treatment.
Cell Biol Int. 2023 May;47(5):833-847. doi: 10.1002/cbin.11979. Epub 2022 Dec 26.
PMID: 36571107
Review.
Today, cancer is one of the main health-related challenges, and in the meantime, breast cancer
(BC) is one of the most common cancers among women, with an alarming
number of incidences and deaths every year. ...After transcription and
edition, these two nonco …
Pristimerin Suppressed Breast Cancer Progression via miR-542-5p/DUB3 Axis.
Onco Targets Ther. 2020 Jul 7;13:6651-6660. doi: 10.2147/OTT.S257329. eCollection 2020.
PMID: 32753899
Free PMC article.
BACKGROUND: Breast cancer is one of the most common and malignant tumors in the world. ...MATERIALS AND METHODS: Breast cancer cell lines MCF-7, MDA-MB-231, and 4T1 were used. Cell Counting Kit-8 (CCK-8) assay was performed to evaluate proliferation vi …
miRNA-dependent regulation of STIM1 expression in breast cancer.
Sci Rep. 2019 Sep 10;9(1):13076. doi: 10.1038/s41598-019-49629-5.
PMID: 31506588
Free PMC article.
Clinically, STIM1 and Ago2 expression levels do not correlate with breast cancer
progression, however in the basal subtype high STIM1 expression is
associated with poorer survival. Our findings show that STIM1 expression
is differentially regulated by the miR …
Inhibitory Effects of Ursolic Acid on the Stemness and Progression of Human Breast Cancer Cells by Modulating Argonaute-2.
Int J Mol Sci. 2022 Dec 26;24(1):366. doi: 10.3390/ijms24010366.
PMID: 36613808
Free PMC article.
Furthermore, the co-reduction in oncogenic miRNA levels
(miR-9 and miR-221) was a result of the down-modulation in AGO2 in breast cancer cells in vitro. Mechanically, UA increases PTEN expression to inactivate the FAK/PI3K/Akt/mTOR signaling pathway and the d …
Biochem Biophys Res Commun. 2020 Oct 15;531(2):256-263. doi: 10.1016/j.bbrc.2020.07.058. Epub 2020 Aug 13.
PMID: 32800344
However, the role of p62 in the breast cancer pathophysiology is still unclear. Here, we aimed to analyze the effect of changes in p62 expression on breast cancer cell lines. ...Moreover, the p62-AGO2-PR axis was identified as a crucial signalin …
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