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miRNA-dependent regulation of STIM1 expression in breast cancer.
Sci Rep. 2019 Sep 10;9(1):13076. doi: 10.1038/s41598-019-49629-5.
PMID: 31506588
Free PMC article.
Here we investigate the role of the microRNA machinery in regulating STIM1 expression. We show that STIM1 expression is regulated post-transcriptionally by the miRNA machinery and identify miR-223 and miR-150 as regulators of STIM1 expres …
Role of tRNAs in Breast Cancer Regulation.
Adv Exp Med Biol. 2021;1187:121-145. doi: 10.1007/978-981-32-9620-6_6.
PMID: 33983576
Review.
With the development of high throughput technologies such
as next-generation sequencing, genome-wide differential tRNA expression
patterns in breast cancer-derived cell lines and breast tumors have been investigated. The genome-wide transcriptomics analyses h …
MicroRNAs in Breast Cancer: One More Turn in Regulation.
Curr Drug Targets. 2016;17(9):1083-100. doi: 10.2174/1389450116666150213114103.
PMID: 25694121
Review.
This review provides an overview of the current situation of miRNAs in breast cancer, focusing on their involvement in resistance and the circulating miRNA. The mechanisms of therapeutic resistance regulated by miRNAs, such as the regu …
Cancer-Associated Fibroblasts: Epigenetic Regulation and Therapeutic Intervention in Breast Cancer.
Cancers (Basel). 2020 Oct 13;12(10):2949. doi: 10.3390/cancers12102949.
PMID: 33066013
Free PMC article.
Review.
Breast cancer is the leading cause of cancer-related mortality in women worldwide. ...These cells are positively linked to breast cancer progression. Breast CAFs can be categorised into distinct subtypes according to their roles in bre …
Dissecting miRNA facilitated physiology and function in human breast cancer for therapeutic intervention.
Semin Cancer Biol. 2021 Jul;72:46-64. doi: 10.1016/j.semcancer.2020.05.017. Epub 2020 Jun 1.
PMID: 32497683
Review.
MicroRNAs (miRNAs) are key epigenomic regulators of biological processes in animals and plants. ...Aberrant regulation of gene expression by miRNAs is frequently observed in cancer. ...
Epigenetic Regulation of microRNAs in Cancer: Shortening the Distance from Bench to Bedside.
Int J Mol Sci. 2021 Jul 8;22(14):7350. doi: 10.3390/ijms22147350.
PMID: 34298969
Free PMC article.
Review.
In this sense, aberrant miRNA landscape evaluation has emerged as a promising strategy for cancer management. In this review, we have focused on the regulation (biogenesis, processing, and dysregulation) of miRNAs and their role as modulators of the ep …
Role of the Mediator Complex and MicroRNAs in Breast Cancer Etiology.
Genes (Basel). 2022 Jan 26;13(2):234. doi: 10.3390/genes13020234.
PMID: 35205279
Free PMC article.
Review.
MED transduces the signal between DNA-bound
transcriptional activators (gene-specific transcription factors) to the
RNA polymerase II transcription machinery to activate transcription. It is known that MED plays an essential role in ER-mediated gene expression mainly throu …
Recent Advances in Comprehending the Signaling Pathways Involved in the Progression of Breast Cancer.
Int J Mol Sci. 2017 Nov 3;18(11):2321. doi: 10.3390/ijms18112321.
PMID: 29099748
Free PMC article.
Review.
This review describes recent advances in the comprehension of signaling pathways involved in breast cancer
progression. Calcium sensing receptor (CaSR), caveolae signaling,
signaling referred to hypoxia-inducing factors and disturbances in the
apoptotic machinery …
KLK6-regulated miRNA networks activate oncogenic pathways in breast cancer subtypes.
Mol Oncol. 2016 Aug;10(7):993-1007. doi: 10.1016/j.molonc.2016.03.008. Epub 2016 Apr 8.
PMID: 27093921
Free PMC article.
KLK6 is expressed in normal mammary tissues and is aberrantly regulated in breast cancer. At physiological levels of expression, i.e. those found in normal mammary tissues, KLK6 acts as a tumor suppressor in human breast cancer. ...Cancer …
Gene. 2018 Jan 30;641:248-258. doi: 10.1016/j.gene.2017.10.018. Epub 2017 Oct 14.
PMID: 29038000
Review.
MicroRNAs (miRNAs) are a class of small, non-coding RNAs that are involved in the regulation
of gene expression at the post-transcriptional level. ...We also
discuss the need for identifying novel HDAC inhibitors for modulation of
miR-200 in triple negative …
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