Neurofibromin 1 gene. NF1 Geeni on tuttu opiskeluajoilta nimellä von Recklinghausen taudista lähinnä ( ihomuutoksia). Osuus syövässä on uudempi löytö.

 https://pubmed.ncbi.nlm.nih.gov/37627552/h

• GeneCards Symbol: NF1 ²
• Neurofibromin 1 ^{2 3 5}
• Neurofibromatosis-Related Protein NF-1 ^{3 4}
• Neurofibromin ^{3 4}
• Von Recklinghausen Disease ²
• Neurofibromatosis 1 ³

• Neurofibromatosis ²
• Watson Disease ²
• NFNS ³
• VRNF ³
• WSS ³

External Ids for NF1 Gene

ttps://www.genecards.org/cgi-bin/carddisp.pl?gene=NF1&keywords=NF

Tässä GeneCards  linkissä on kovasti asiaa. 

Tässä otan esiin *prolaktiinisignaloinnin kartan Geneards lähteestä  ja koetan tehdä muistiinpanot omaan vihkoon sen verkostosta tänään.  11.3. 2024.

NCBI Gene Summary for NF1 Gene

• This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NF1 Gene

 NF1 (Neurofibromin 1) is a Protein Coding gene. Diseases associated with NF1 include Neurofibromatosis-Noonan Syndrome and Neurofibromatosis, Type I. Among its related pathways are RAF/MAP kinase cascade and *Prolactin Signaling. Gene Ontology (GO) annotations related to this gene include binding and phosphatidylcholine binding. An important paralog of this gene is SYNGAP1.

UniProtKB/Swiss-Prot Summary for NF1 Gene

Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. ( NF1_HUMAN,P21359 )

 https://pathcards.genecards.org/card/prolactin_signaling