SIMTRONS, simtronit

Biogenesis of mammalian microRNAs by a non-canonical processing pathway.

Havens MA, Reich AA, Duelli DM, Hastings ML. Nucleic Acids Res. 2012 May;40(10):4626-40. doi: 10.1093/nar/gks026. Epub 2012 Jan 23. PMID: 22270084 Free PMC article.

However, simtron biogenesis was reduced by expression of a dominant negative form of Drosha. Simtrons are bound by Drosha and processed in vitro in a Drosha-dependent manner. Both simtrons and mirtrons function in silencing of target transcripts and are found in the …