AGOTRONS, agotronit

 

1

The agotrons: Gene regulators or Argonaute protectors?

Stagsted LV, Daugaard I, Hansen TB. Bioessays. 2017 Apr;39(4). doi: 10.1002/bies.201600239. Epub 2017 Mar 7. PMID: 28266707 Review.

Agotrons are found in most mammals and associate with Ago as 100 nucleotide (nt) long RNA species. Here, we speculate on the functional and biological relevance of agotrons: (i) agotrons could serve as non-promiscuous miRNA-like regulators with reduced off-ta …

2

Detecting Agotrons in Ago CLIPseq Data.

Hansen TB. Methods Mol Biol. 2018;1823:221-232. doi: 10.1007/978-1-4939-8624-8_17. PMID: 29959685

We recently identified a novel class of gene regulators, the agotrons. Agotrons derive from short introns and associate with Argonaute (Ago) proteins much similar to miRNAs. ...As a class, agotrons are conserved in mammals, and despite the non-canonical bioge …

3

Biogenesis and Function of Ago-Associated RNAs.

Daugaard I, Hansen TB. Trends Genet. 2017 Mar;33(3):208-219. doi: 10.1016/j.tig.2017.01.003. Epub 2017 Feb 4. PMID: 28174021 Review.

However, more exotic miRNA-like species that bypass particular steps of the canonical miRNA biogenesis pathway continue to emerge, with one of the most recent additions being the agotrons, which escape both Drosha/DGCR8- and Dicer-processing. We review here the current kno …

4

Argonaute-associated short introns are a novel class of gene regulators.

Hansen TB, Venø MT, Jensen TI, Schaefer A, Damgaard CK, Kjems J. Nat Commun. 2016 May 13;7:11538. doi: 10.1038/ncomms11538. PMID: 27173734 Free PMC article.

Some agotrons are completely conserved in mammalian species, suggesting that they are functionally important. Furthermore, we demonstrate that the agotrons are capable of repressing mRNAs with seed-matching target sequences in the 3'-UTR. ...