KLHL31 (6p12.1), KBTBD1, BKLHD6, BTB and Kelch Domain Containing protein 6 , Kelch Like 31

Aliases for KLHL31 Gene

• Kelch Like Family Member 31 ^{2 3 5}
• Kelch Repeat And BTB Domain-Containing Protein 1 ^{3 4}
• Kelch Repeat And BTB (POZ) Domain Containing 1 ^{2 3}
• BTB And Kelch Domain-Containing Protein 6 ^{3 4}
• Kelch-Like Protein KLHL ^{3 4}
• Kelch-Like Protein 31 ^{3 4}

• KBTBD1 ^{3 4}
• BKLHD6 ^{3 4}
• KLHL ^{3 4}
• Kelch-Like 31 (Drosophila) ²
• BA345L23.2 ³
•  ^{https://www.ncbi.nlm.nih.gov/protein/NP_001003760.2}

  ORIGIN      
          1 mapkkkivkk nkgdinemti ivedsplnkl nalngllegg nglscissel tdasygpnll
         61 eglskmrqen flcdlvigtk tksfdvhksv mascseyfyn ilkkdpsiqr vdlndisplg
        121 latviayayt gkltlslyti gsiisaavyl qihtlvkmcs dfliremsve ncmyvvniae
        181 tyslknakaa aqkfirdnfl efaesdqfmk ltfeqinell idddlqlpse ivafqiamkw
        241 lefdqkrvky aadllsnirf gtisaqdlvn yvqsvprmmq dadchrllvd amnyhllpyh
        301 qntlqsrrtr irggcrvlvt vggrpgltek slsrdilyrd pengwsklte mpaksfnqcv
        361 avmdgflyva ggedqndarn qakhavsnfc rydprfntwi hlasmnqkrt hfslsvfngl
        421 vyaaggrnae gslaslecyv pstnqwqpkt plevarccha savadgrvlv tggyianays
        481 rsvcaydpas dswqelpnls tprgwhcavt lsdrvyvmgg sqlgprgerv dvltvecysp
        541 atgqwsyaap lqvgvstagv salhgraylv ggwnegekky kkciqcfspe lnewteddel
        601 peatvgvscc tlsmpnnvtr esrassvssv pvsi
  //

  LxxLL motiivi 

External Ids for KLHL31 Gene

OMIM https://www.omim.org/entry/610749

* 610749

KELCH-LIKE 31; KLHL31

Alternative titles; symbols

KLHL

HGNC Approved Gene Symbol: KLHL31

Cytogenetic location: 6p12.1     Genomic coordinates (GRCh38): 6:53,647,915-53,665,853 (from NCBI)

TEXT

▼ Cloning and Expression

Wu and Gong (2004) identified a novel kelch-like gene in zebrafish by a whole-mount in situ hybridization screen for genes involved in embryogenesis. By database analysis with the sequence of this gene, designated klhl, they identified orthologs in human (KLHL31), mouse, rat, and pufferfish. The deduced human KLHL31 protein contains 634 amino acids, with a kelch repeat domain in the C terminus and a BTB/POX domain in the N terminus. The human and zebrafish proteins share approximately 72% sequence identity. Northern blot analysis of human tissues detected a single 6-kb KLHL31 transcript with strong expression in skeletal muscle and weak expression in heart, consistent with the expression pattern in zebrafish

▼ Mapping

By sequence analysis, Wu and Gong (2004) mapped the zebrafish klhl gene to linkage group (LG) 13, and the human KLHL31 gene to a region of syntenic homology on chromosome 6p12. They also mapped the mouse and rat klhl orthologs to regions of syntenic homology on chromosome 9 and chromosome 8, respectively.

▼ REFERENCES

1. 
   
   
   

   Wu, Y. L., Gong, Z. A novel zebrafish kelchlike gene klhl and its human ortholog KLHL display conserved expression patterns in skeletal and cardiac muscles. Gene 338: 75-83, 2004. [PubMed: 15302408, related citations] [Full Text]

Creation Date:

Carol A. Bocchini : 2/7/2007

Edit History:

carol : 02/07/2007