KLHL1 (13q21.33), MRP2, Mayven.proteiinin kaltainen 2.

KLHL1 , MRPS (13q21.33), Mayven related protein 2
https://www.ncbi.nlm.nih.gov/gene/57626

 NP_001273654.1

REFERENCE   5  (residues 1 to 687)
  AUTHORS   Aromolaran KA, Benzow KA, Cribbs LL, Koob MD and Piedras-Renteria
            ES.
  TITLE     T-type current modulation by the actin-binding protein Kelch-like 1
  JOURNAL   Am. J. Physiol., Cell Physiol. 298 (6), C1353-C1362 (2010)
   PUBMED   20147652
  REMARK    GeneRIF: KLHL1 interacts with Cav3.2 and modulates T-type calcium
            currents by increasing current deactivation kinetics and current
            density and calcium influx.

REFERENCE   6  (residues 1 to 687)
  AUTHORS   Chen WL, Lin JW, Huang HJ, Wang SM, Su MT, Lee-Chen GJ, Chen CM and
            Hsieh-Li HM.
  TITLE     SCA8 mRNA expression suggests an antisense regulation of KLHL1 and
            correlates to SCA8 pathology
  JOURNAL   Brain Res. 1233, 176-184 (2008)
   PUBMED   18708037
  REMARK    GeneRIF: KLHL1 was expressed in human brain and kidney, but was
            also in other tissues, such as prostate gland, small intestine,
            colon, testis (but not the ovaries), liver and pancreas.
REFERENCE   7  (residues 1 to 687)
  AUTHORS   Aromolaran KA, Benzow KA, Koob MD and Piedras-Renteria ES.
  TITLE     The Kelch-like protein 1 modulates P/Q-type calcium current density
  JOURNAL   Neuroscience 145 (3), 841-850 (2007)
   PUBMED   17289272
  REMARK    GeneRIF: modulatory effect of KLHL1 on the P/Q-type calcium channel
            function, suggesting a possible novel role for KLHL1 in cellular
            excitability.
REFERENCE   8  (residues 1 to 687)
  AUTHORS   Seng S, Avraham HK, Jiang S, Venkatesh S and Avraham S.
  TITLE     KLHL1/MRP2 mediates neurite outgrowth in a glycogen synthase kinase
            3beta-dependent manner
  JOURNAL   Mol. Cell. Biol. 26 (22), 8371-8384 (2006)
   PUBMED   16982692
  REMARK    GeneRIF: This study provides, for the first time, insights into the
            involvement of MRP2 in neurite outgrowth, which occurs in a
            GSK3beta-dependent manner.
REFERENCE   9  (residues 1 to 687)
  AUTHORS   Nemes JP, Benzow KA, Moseley ML, Ranum LP and Koob MD.
  TITLE     The SCA8 transcript is an antisense RNA to a brain-specific
            transcript encoding a novel actin-binding protein (KLHL1)
  JOURNAL   Hum. Mol. Genet. 9 (10), 1543-1551 (2000)

https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=276965 

ORIGIN      
        1 msgsgrkdfd vkhilrlrwk lfshpspstg gpagggclqq dgsgsfehwg psqsrllksq
       61 ersgvstfwk kpssssssss spssssssfn plngtllpva trlqqgapgq gtqqpartlf
      121 yvesleeevv pgmdfpgphe kglvlqelkv epdnssqatg egcghrlvls svsdyfaamf
      181 tsdvceakqe eikmegidpn alwdlvqfay tgclelkedt ienllaaacl lqlpqvvevc
      241 chflmkllhp snclgirafa daqgcielmk vahsytmeni mevirnqefl llpaeelhkl
      301 lasddvnvpd eetifhalmm wvkydmqsrc ndlsmllafi rlpllppqil adlenhalfk
      361 ndlecqklil eamkyhllpe rrtlmqsprt kprkstvgtl yavggmdnnk gattiekydl
      421 rtnlwiqagm mngrrlqfgv aviddklfvi ggrdglktln tvecynpktk twtvlppmst
      481 hrhglgvtvl egpiyavggh dgwsylntve rwdpqsqqwt fvasmsiars tvgvaalngk
      541 lysvggrdgs sclssmeyyd phtnkwnmca pmckrrggvg vatcdgflya vgghdapasn
      601 hcsrlldyve rydpktdtwt mvaplsmprd avgvcllgdr lyavggydgq tylntmesyd
      661 pqtnewtqma slnigragac vvvikqp
//

Neuroscience. 2007 Mar 30;145(3):841-50. Epub 2007 Feb 6.

The Kelch-like protein 1 modulates P/Q-type calcium current density.  Abstract

The actin-binding protein Kelch-like 1 (KLHL1) is a neuronal protein that belongs to the evolutionarily-conserved Kelch protein super-family. The mammalian KLHL1 is brain-specific, cytosolic and can form multimers and bind actin filaments. KLHL1's function is likely that of an actin-organizing protein, possibly modulating neurite outgrowth, the dynamic morphology of dendritic spine heads; or anchoring proteins essential for post-synaptic function, like ion channels. Targeted deletion of the KLHL1 gene in Purkinje neurons results in dendritic deficits in these neurons, abnormal gait, and progressive loss of motor coordination in mice [He Y, Zu T, Benzow KA, Orr HT, Clark HB, Koob MD (2006) Targeted deletion of a single SCA8 ataxia locus allele in mice causes abnormal gait, progressive loss of motor coordination, and Purkinje cell dendritic deficits.

 J Neurosci 26:9975-9982]. Here we tested the hypothesis that KLHL1 may interact and modulate voltage-gated calcium channels by assessing the interaction of the principal subunit of P/Q-type channels, alpha(1A), with KLHL1

10.1016/j.neuroscience.2006.12.046