KLHDC2 (14q21.3), LCP, HCLP1,HCLP-1

https://www.ncbi.nlm.nih.gov/gene/23588

Also known as

LCP; HCLP1; HCLP-1

Expression

Ubiquitous expression in thyroid (RPKM 22.9), kidney (RPKM 22.5) and 25 other tissues See more

Preferred Names

kelch domain-containing protein 2

Names

hepatocellular carcinoma-associated antigen 33

host cell factor homolog LCP

host cell factor-like protein 1

1.   mRNA and Protein(s)
2. NM_014315.3 → NP_055130.1  kelch domain-containing protein 2
   See identical proteins and their annotated locations for NP_055130.1
   

   ORIGIN      
           1 madgnedlra ddlpgpafes yesmelacpa ersghvavsd grhmfvwggy ksnqvrglyd
          61 fylpreelwi ynmetgrwkk integdvpps msgscavcvd rvlylfgghh srgntnkfym
         121 ldsrstdrvl qweridcqgi ppsskdklgv wvyknkliff ggygylpedk vlgtfefdet
         181 sfwnsshprg wndhvhildt etftwsqpit tgkapspraa hacatvgnrg fvfggryrda
         241 rmndlhylnl dtwewnelip qgicpvgrsw hsltpvssdh lflfggfttd kqplsdawty
         301 cisknewiqf nhpytekprl whtacasdeg evivfggcan nllvhhraah sneilifsvq
         361 pkslvrlsle avicfkemla nswnclpkhl lhsvnqrfgs nntsgs
   //

   Conserved Domains (3) summary

   sd00038
   Location:218 → 265

   Kelch; KELCH repeat [structural motif]

   pfam13415
   Location:279 → 326

   Kelch_3; Galactose oxidase, central domain

   cl26061
   Location:29 → 296

   PLN02193; nitrile-specifier protein

3. Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2. Chin KT, et al. Mol Cell Biochem, 2007 Feb. PMID 16964437
4. Recognition of the Diglycine C-End Degron by CRL2^KLHDC2 Ubiquitin Ligase. Rusnac DV, et al. Mol Cell, 2018 Dec 6. PMID 30526872,
5. Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein. Zhou HJ, et al. J Biol Chem, 2001 Aug 3. PMID 11384994
6. Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. Wang Y, et al. J Immunol, 2002 Jul 15. PMID 12097419Autoantibodies are often detected in hepatocellular carcinoma (HCC), and these responses may represent recognition of tumor Ags that are associated with transformation events. The identities of these Ags, however, are less well known. Using serological analysis of recombinant cDNA expression libraries (SEREX) from four HCC patients, we identified 55 independent cDNA sequences potentially encoding HCC tumor Ags. Of these genes, 15 are novel. Two such proteins, HCA587 and HCA661, were predominantly detected in testis, but not in other normal tissues, except for a weak expression in normal pancreas. In addition to HCC, these two Ags can be found in cancers of other histological types. Therefore, they can be categorized as cancer-testis (CT) Ags. Two other Ags (HCA519 and HCA90) were highly overexpressed in HCC and also expressed in cancer cell lines of lung, prostate, and pancreas, but not in the respective normal tissues. Four other Ags were identified to be expressed in particular types of cancer cell lines (HCA520 in an ovarian cancer cell line, HCA59 and HCA67 in a colon cancer cell line, HCA58 in colon and ovarian cancer cell lines), but not in the normal tissue counterpart(s). In addition, abundant expression of complement inactivation factors was found in HCC. These results indicate a broad range expression of autoantigens in HCC patients. Our findings open an avenue for the study of autoantigens in the transformation, metastasis, and immune evasion in HCC.
7. Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases. Mahrour N, et al. J Biol Chem, 2008 Mar 21. PMID 18187417

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene