Kelch proteiinit lihastaudeissa ( katsaus 2014, Gupta, Beggs, jatkoa, fylogeneettinen puu ), KLHL, KBTBD, KLHDC alaperheet

Figure 2https://media.springernature.com/full/springer-static/image/art%3A10.1186%2F2044-5040-4-11/MediaObjects/13395_2014_Article_102_Fig2_HTML.jpg?as=webp

From: Kelch proteins: emerging roles in skeletal muscle development and diseases

Phylogenetic analysis showing relationships between human Kelch protein family members. (A) Phylogenetic tree of full-length amino acid sequences of human proteins were aligned. (B) Phylogenetic tree of amino acid sequences of Kelch domains. Phylogenetic trees were constructed by maximum-likelihood method using BLOSUM matrix in MEGA 6.06. Reference sequences used for alignments are indicated at right of each protein name. Blue highlighting indicates KBTBD subfamily members; green indicates

The Kelch Superfamily. (A) The Kelch family consists of 63 proteins that are subclassified in to KLHL, KBTBD and KLHDC subfamilies. (B) Structure of Kelch domain of rat KLHL41 (PDB code 2WOZ) comprising six repeats that form the complete Kelch domain. The structure was generated using PyMOL (http://www.pymol.org)
. (C) Prototype members of different subfamilies showing different domain organization.
 KLHL proteins have an N-terminal BTB/POZ, a BACK and C-terminal Kelch repeats.
 KBTBD proteins contain an N-terminal BTB domain and Kelch repeats. The BACK domain is normally absent in KBTBD proteins.
 KLHDC proteins lack both BTB/POZ and BACK domains and contain either Kelch repeats alone or with other domains such as transmembrane (for example, KLHDC7A), Glycine rich (for example, KLHDC10), or Lish and CTLH domains (for example, MKLN1).