Kelch superperheen jaoittelu 5 ryhmään ; Esim. Kelch-Like proteins (1-42) ovat KLHL perhe

Kelch-like protein 32 (KLHL32) belongs to the KLHL family

^[1]. Its function is not clear.

The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding

^[1], while the Kelch domain (repeats) form beta-propellers. The Kelch superfamily of proteins can be subdivided into five groups: 

(1) N-propeller, C-dimer proteins, 

(2) N-propeller proteins,

 (3) propeller proteins,

 (4) N-dimer, C-propeller proteins, and

 (5) C-propeller proteins.

 KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins ^[2]

. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins

^[3]. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases ^{[4, 5]}