(2) ZMIZ2 (7p13), TRAFIP20, PIAS-proteiinin kaltainen AR-interaktori ZIMP7

(2) ZMIZ2,(TRAFIP20) (7) https://www.ncbi.nlm.nih.gov/gene/83637

ZMIZ2 zinc finger MIZ-type containing 2 [ Homo sapiens (human) ]

Also known as

NET27; ZIMP7; hZIMP7; TRAFIP20

Summary

ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]

Expression

Ubiquitous expression in spleen (RPKM 17.3), skin (RPKM 13.4) and 25 other tissues See more

Orthologs mouse all

Preferred Names

zinc finger MIZ domain-containing protein 2

Names

PIAS-like protein Zimp7

Peptide, history:

NP_001287888.1  zinc finger MIZ domain-containing protein 2 isoform 3

Conserved Domains (3) summary

cd16791
Location:539 → 586

SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

cl25887
Location:149 → 265

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cl26247
Location:215 → 330

DNA_pol3_delta2; DNA polymerase III, delta subunit

Related articles in PubMed

1. The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor. Lee J, et al. Nucleic Acids Res, 2007. PMID 17584785, Free PMC Article
2. hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes. Huang CY, et al. Mol Endocrinol, 2005 Dec. PMID 16051670
3. A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription. Peng Y, et al. J Biol Chem, 2010 Apr 9. PMID 20159969, Free PMC Article
4. Selection system for genes encoding nuclear-targeted proteins. Ueki N, et al. Nat Biotechnol, 1998 Dec. PMID 9853615
5. Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase. Delker RK, et al. Proc Natl Acad Sci U S A, 2013 Jan 15. PMID 23277564, Free PMC Article

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

1. there is an interaction between Zimp7 and PIAS proteins with higher preference for PIAS3, in androgen receptor-mediated transcription
2. hZimp7 modulates androgen receptor and/or other nuclear receptor-mediated transcription, possibly through alteration of chromatin structure by SWI/SNF-like BAF complexes.