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torsdag 16 maj 2019

Polyubikitiiniketjun erilaisia muotoja

Sinkkikoordinaatiolla on  osuutta tuon  mutkallisen muodon syntymiseen.  Toisessa monoubikitiinissä on  C-terminaalissa fuusioproteiiniosassa  sinkkikoordinaatiotyyppi Zn C(4)  joka muodostuu samaan tapaan kuin   raudan ja rikin  koordinaatio,

https://www.researchgate.net/figure/Various-types-of-ubiquitination-and-the-specific-role-of-Ub-chain-linkages-Ub-is_fig3_263099901
 Various types of ubiquitination and the specific role of Ub chain linkages. Ub is composed of 76 amino acids and forms isopeptide linkages between the carboxyl group of Gly76 residue and ε -amino group of Lys residue in substrate or in another Ub molecule. The sub- strate can be monoubiquitinated, multi-monoubiquitinated, or polyubiquitinated with different types of chain linkages. The 1 st Met and seven Lys residues in Ub (Lys6, Lys11, Lys27, Lys29, Lys33, Lys48, and Lys63) can all form specific chain linkages with distinct conformations and can exert specific (or unknown) functions. Although it is rare, heterogeneous and branched/forked chain linkages are also possible. 
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