(6) ZMIZ6 (19p13.3), E3-SUMO proteiiniligaasi PIAS4,PIASy , Aktivoidun STAT4:n inhibiittori

PIAS4 protein inhibitor of activated STAT 4 [ Homo sapiens (human) ]

(6)  ZMIZ6, (PIAS4), (19), https://www.ncbi.nlm.nih.gov/gene/51588

PIAS4 ,Also known as

PIASY; Piasg; ZMIZ6; PIAS-gamma

Expression

Broad expression in testis (RPKM 14.8), spleen (RPKM 3.8) and 25 other tissues See more

Orthologs

mouse all

Preferred Names

E3 SUMO-protein ligase PIAS4

Names

RING-type E3 ubiquitin transferase PIAS4

protein inhibitor of activated STAT protein 4

protein inhibitor of activated STAT protein PIASy

protein inhibitor of activated STAT protein gamma

zinc finger, MIZ-type containing 6

Peptide structure, History:

NP_056981.2  E3 SUMO-protein ligase PIAS4

Conserved Domains (3) summary

smart00513
Location:12 → 46

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

pfam02891
Location:322 → 371

zf-MIZ; MIZ/SP-RING zinc finger

pfam14324
Location:131 → 269

PINIT; PINIT domain

Related articles in PubMed

1. Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response. Conn KL, et al. J Virol, 2016 May. PMID 26937035, Free PMC Article
2. Protein inhibitor of activated STAT xα depresses cyclin D and cyclin D kinase, and contributes to the inhibition of osteosarcoma cell progression. Wang J, et al. Mol Med Rep, 2016 Feb. PMID 26708148
3. PIAS4 is associated with macro/microcephaly in the novel interstitial 19p13.3 microdeletion/microduplication syndrome. Nevado J, et al. Eur J Hum Genet, 2015 Dec. PMID 25853300, Free PMC Article
4. PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy. Naidu SR, et al. Cell Cycle, 2012 Jul 15. PMID 22751435, Free PMC Article
5. PIAS4 represses vitamin D receptor-mediated signaling and acts as an E3-SUMO ligase towards vitamin D receptor. Jena S, et al. J Steroid Biochem Mol Biol, 2012 Oct. PMID 22564762

See all (112) citations in PubMed GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Investigation of the mechanisms responsible for the alcohol action revealed that alcohol enhanced the expression of protein inhibitor of activated STAT (PIASy) and overexpression of PIASy compromised anti-hepatitis C virus ability of IFN-lambda1.
2. study demonstrates that Piasy may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses
3. In the present study, the protein inhibitor of activated STAT Y (PIASy) was identified as a novel Isl1-interacting protein. Furthermore, PIASy and Isl1 upregulate insulin gene expression and insulin secretion in a dose-dependent manner by activating the insulin promoter.
4. post-translational modification of Nkx3.2 employing HDAC9-PIASy-RNF4 axis plays a crucial role in controlling chondrocyte viability and hypertrophic maturation during skeletal development in vertebrates.
5. new protein isoform encoded by KIAA0317, termed fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates the TGFbeta signaling pathway through the site-specific ubiquitination of PIAS4.
6. these findings provide evidence for the effects of PIAsxalpha and its mechanism on osteosarcoma progression, which offers novel insight into sumoylation and the cell cycle in osteosarcoma.
7. PIAS4 was identified as a candidate gene for abnormal head size in 13 patients with proximal 19p13.3 submicroscopic rearrangements .
8. Our data reveal a novel and dynamic role for PIAS4 in the cellular-mediated restriction of herpesviruses and establish a new functional role for the PIAS family of SUMO ligases in the intrinsic antiviral immune response to DNA virus infection.
9. PIAS4 activity are required for the AMPKalpha1 SUMOylation and the inhibition of AMPKalpha1 activity towards mTORC1 signalling.
10. PIAS4 (rs735842) and VEGFA (rs699947) were the most statistically significant variants associated in hypoxia pathway analysis.

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