SOLUSYKLI: ADNP, Zf Homeobox-proteiini. Aktiviteetistä riippuva neuroprotektiivinen tekijä

tisdag 28 maj 2019

ADNP

https://www.omim.org/entry/611386
ADNP is homeodomain-containing zinc finger protein with transcription factor activity that is essential for brain formation (Gozes, 2007; Mandel et al., 2007). ADNP interacts with components of the BAF complex, the eukaryotic equivalent of the SWI/SNF complex in yeast that is involved in the regulation of gene expression (summary by Helsmoortel et al., 2014). See, e.g., ARID1A (603024

https://www.ncbi.nlm.nih.gov/gene/23394

Also known as: ADNP1; HVDAS; MRD28
Summary Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Expression Ubiquitous expression in testis (RPKM 11.8), ovary (RPKM 8.8) and 25 other tissues See more Orthologs mouse all

Names

ADNP homeobox 1

activity-dependent neuroprotective protein

Conserved Domains (2) summary