Ubikitiinikonjugaasientsyymit UBE2 eri kromosomeissa ( 38 kpl mainittuna)

•   APULUETTELO

  UBE2 geenien aakkoselliset nimet, sijainti eri kromosomeissa.
  Kromosomissa 1 esiintyvät UBE2 -geenit: J2, U,  (p-haarassa) ,T ja Q1 (q haarassa)
  Kromosomisasa 2 esiintyvät  BIRC6 ja UBE2 geenit: BIRC6, (p-haarassa) E3 ja F (q-haarassa).
  Kromosomissa 3 esiintyvät UBE2-geenit ja APG: E1 ja E2 (p-haarassa) ATG3 (q-haarassa). 
  Kromosomissa 4 esiintyvät UBE2- geenit: K ( p-haarassa), D3 (q-haarassa).
   Kromosomissa 5 esiintyvät  APG ja UBE2-geenit: ATG10, B ja D2 (q-haarassa).
  Kromosomissa 6 esiintyvä UBE2 -geeni: J1 (q-haarassa).
  Kromosomissa 7 esiintyvä UBE2-geeni: D4 (p-haarassa) , H ( q-haarassa)
  Kromosomissa 8 esiintyvät UBE2-geenit: W ja V2 (q-haarassa).
  Kromosomissa 9 esiintyvä UBE2-entsyymi: R2 (q-haarassa).
  Kromosomissa 10 esiintyvä UBE2-geeni: D1 (q-haarassa)
  Kromosomissa 11 esiintyvä UBE2-entsyymi: L6 (q-haarassa).
  Kromosomissa 12 esiintyvä UBE2 geeni: N  (q.-haarassa).
  Kromosomissa 15 esiintyvä UBE2-geeni Q2 (q-haarassa).
  Kromosomissa 16 esiintyvä UBE2-geeni: I (p-haarassa).
  Kromosomissa 17 esiintyvät UBE2-geeni: G1 (p-haarassa), Z ja O (q-haarassa).
  Kromosomissa 19 esiintyvät UBE2-geenit: R1 (p-haarassa) , S ja M (q-haarassa).
  Kromosomissa 20 esiintyvät UBE2-geenit: C ja V1 (q-haarassa) .
  Kromosomissa 21 esiintyy UBE2-geeni: G2 (q-haarassa).
  Kromosomissa 22 esiintyy UBE2-geeni: L3 (q-haarassa). 
  Kromosomi 23 X omaa UBE2-geenit: A ja NL ( q-haarassa). 
  Muistiin ubikitiini- E2 kuljettajista(ubc)  eli E2- konjugaaseista, joita on n. 40 tunnettua.
   25.6. 2018  Päivitys 15.5. 2019. Tässä on vain 38.

  Kromosomi 1

(1) UBE2J2, (1p36.33). https://www.ncbi.nlm.nih.gov/gene/?term=UBE2J2+%2C+Human

NCUBE-2, NCUBE2, pro2121.Non-canonicalr Ubiquitin Conjugating Enzyme 2.

(2) UBE2Q1, (1q21.3). https://www.ncbi.nlm.nih.gov/gene/55585

Nimet GTAP, galactosyl transferase associated protein; NICE-5, NICE5, PRO 3094, UBE2Q, .

(3) UBE2T, (1q32.1). https://www.ncbi.nlm.nih.gov/gene/29089

Nimet: FANCT ( geenidefekti assosioituu Fanconin anemiaan komplementaatioryhmä T), HSPC150, PIG50 ( Cell-proliferation inducing gene 50 protgein).

(4) UBE2U, (1p31.3). https://www.ncbi.nlm.nih.gov/gene/148581

https://www.ncbi.nlm.nih.gov/pubmed/27903633/

• Kromosomi 2

(5) UBE2E3, (2q31.3). https://www.ncbi.nlm.nih.gov/gene/10477

UBCH9, UbcM2, UBE2-23kDa.

Expr. Gallabladder, thyroid. Deficiency: Cellular senewscence, Important for retinal pigment cell proliferation.

(6) UBE2F, (2q37.2). https://www.ncbi.nlm.nih.gov/gene/140739

NCE2, NEDD Carrier protein UBE2F

NEDD8-conjugating enzyme UBE2F,

RING-type E3 NEDD8 transferase UBE2F.

Ubiquitin conjugating enzyme E2F putative

(7) BIRC6, (2p22.3). https://www.ncbi.nlm.nih.gov/gene/57448

Expr. Thyroid, ovary.

APOLLON, BRUCE. Protein with BIR( baculoviral) and UBC c (UBCE2 catalytic) domain. Inhibits apoptosis by facilitating degradation of apoptotiv proteins.

Preferred Names baculoviral IAP repeat-containing protein 6

Names BIR repeat-containing ubiquitin-conjugating enzyme (BRUCE)

RING-type E3 ubiquitin transferase BIRC6

ubiquitin-conjugating BIR-domain enzyme apollon

• Kromosomi 3

(8) UBE2E1, (3p24.2). https://www.ncbi.nlm.nih.gov/gene/7324

UCH6, Expr. Lymp node, brain.

OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination. Pasupala N, et al. J Biol Chem, 2018 Nov 23. PMID 30282802, Free PMC Article

Microarray-based analysis and clinical validation identify ubiquitin-conjugating enzyme E2E1 (UBE2E1) as a prognostic factor in acute myeloid leukemia.

Preferred Names ubiquitin-conjugating enzyme E2 E1

Names (E3-independent) E2 ubiquitin-conjugating enzyme E1

E2 ubiquitin-conjugating enzyme E1

ubiquitin carrier protein E1

ubiquitin conjugating enzyme E2E 1

ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)

ubiquitin-conjugating enzyme E2E 1 (homologous to yeast UBC4/5)

ubiquitin-protein ligase E1

(9) UBE2E2, (3p24.3) .https://www.ncbi.nlm.nih.gov/gene/7325

Expr. brain, fat. Gene assosiates to Diabetes mellitustype 2 and decreased glucose-stimualted insulin release.

Preferred Names ubiquitin-conjugating enzyme E2 E2

Names E2 ubiquitin-conjugating enzyme E2

ubiquitin carrier protein E2

ubiquitin conjugating enzyme E2E 2

ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)

ubiquitin-conjugating enzyme E2E 2 (homologous to yeast UBC4/5)

ubiquitin-protein ligase E2

Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus. Kim JY, et al. Gynecol Endocrinol, 2013 Oct. PMID 23862583

• Associations between changes in the maternal gut microbiome and differentially methylated regions of diabetes-associated genes in fetuses: A pilot study from a birth cohort study. Tachibana K, et al. J Diabetes Investig, 2017 Jul. PMID 27863092, Free PMC Article

• Type 2 Diabetes Risk Allele UBE2E2 Is Associated With Decreased Glucose-Stimulated Insulin Release in Elderly Chinese Han Individuals. Xu K, et al. Medicine (Baltimore), 2016 May. PMID 27175665, Free PMC Article

(10) ATG3, (3q13.2).https://www.ncbi.nlm.nih.gov/gene/64422

Expr. Tetis, bone marrow.

APG3; APG3L; PC3-96; APG3-LIKE

https://www.ncbi.nlm.nih.gov/pubmed/29300789/

M.Tbc miRNA-155 is an inhibitor of ATG:.

Preferred Names of ATG: ubiquitin-like-conjugating enzyme ATG3

Names 2610016C12Rik

APG3 autophagy 3-like

ATG3 autophagy related 3 homolog

autophagy-related protein 3

hApg3

• Kromosomi 4

(11) UBE2D3, (4q24). https://www.ncbi.nlm.nih.gov/gene/7323

Expr. Bone marrow, thyroid.

E2(17)KB3, UBC4/5, UBCH5C.

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017]

RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells.

Preferred Names ubiquitin-conjugating enzyme E2 D3

Names: (E3-independent) E2 ubiquitin-conjugating enzyme D3

E2 ubiquitin-conjugating enzyme D3

ubiquitin carrier protein D3

ubiquitin conjugating enzyme E2D 3

ubiquitin-conjugating enzyme E2(17)KB 3

ubiquitin-conjugating enzyme E2-17 kDa 3

ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)

ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5)

ubiquitin-protein ligase D3

(12) UBE2K, (4p14).https://www.ncbi.nlm.nih.gov/gene/3093

Expr. Brain, thyroid.

LIG; HIP2; HYPG; UBC1; E2-25K

Summary The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

https://www.ncbi.nlm.nih.gov/pubmed/10675012/

LIG= LDL-inducable gene.

Preferred Names ubiquitin-conjugating enzyme E2 K

Names E2 ubiquitin-conjugating enzyme K

E2(25K)

HIP-2

huntingtin-interacting protein 2

ubiquitin carrier protein

ubiquitin conjugating enzyme E2K

ubiquitin-conjugating enzyme E2(25K)

ubiquitin-conjugating enzyme E2-25 KDA

ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)

ubiquitin-protein ligase

• Kromosomi 5

(13) UBE2B, (5q31.1).https://www.ncbi.nlm.nih.gov/gene/7320

Expr. Adrenal, heart.

HR6B; UBC2; HHR6B; RAD6B; E2-17kDa

This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]

Preferred Names

ubiquitin-conjugating enzyme E2 B

Names

E2 protein

E2 ubiquitin-conjugating enzyme B

RAD6 homolog B

ubiquitin carrier protein B

ubiquitin conjugating enzyme E2B

ubiquitin-conjugating enzyme E2-17 kDa

ubiquitin-conjugating enzyme E2B (RAD6 homolog)

ubiquitin-protein ligase B

(14) UBE2D2, (5q31.2).https://www.ncbi.nlm.nih.gov/gene/7322

Expr. Testis, brain.

E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B.

This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

https://www.ncbi.nlm.nih.gov/pubmed/30523153/

Preferred Names ubiquitin-conjugating enzyme E2 D2

Names

(E3-independent) E2 ubiquitin-conjugating enzyme D2

E2 ubiquitin-conjugating enzyme D2

p53-regulated ubiquitin-conjugating enzyme 1

ubiquitin carrier protein D2

ubiquitin conjugating enzyme E2D 2

ubiquitin-conjugating enzyme E2-17 kDa 2

ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5)

ubiquitin-protein ligase D2

(15) ATG10, (5q14.1-14.2). https://www.ncbi.nlm.nih.gov/gene/83734

Expr. Testis, thyroid.

APG10, APG10L, pp12616.

Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008] .

Preferred Names ubiquitin-like-conjugating enzyme ATG10

Names

APG10 autophagy 10-like

ATG10 autophagy related 10 homolog

autophagy-related protein 10

• Kromosomi 6

(16) UBE2J1, (6q15). https://www.ncbi.nlm.nih.gov/gene/51465

Expr. Lymph node, bone marrow.

CGI-76, HSPC153, HSPC205, HSU93243, NCUBE1, NCUB1, UBC6, UBC6E, Ubc6p.

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]

Preferred Names ubiquitin-conjugating enzyme E2 J1

Names E2 ubiquitin-conjugating enzyme J1

HSUBC6e

non-canonical ubiquitin-conjugating enzyme 1

ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)

ubiquitin-conjugating enzyme E2, J1, U

yeast ubiquitin-conjugating enzyme UBC6 homolog E

Protein quality control: https://www.ncbi.nlm.nih.gov/pubmed/12082160/

• Kromosomi 7

(17) UBE2D4,(7p13).https://www.ncbi.nlm.nih.gov/gene/51619

Expr. Brain, heart.

HBUCE1

Preferred Names ubiquitin-conjugating enzyme E2 D4

Names

E2 ubiquitin-conjugating enzyme D4

ubiquitin carrier protein D4

ubiquitin conjugating enzyme E2D 4 (putative)

ubiquitin-conjugating enzyme HBUCE1

ubiquitin-protein ligase D4

(18) UBE2H (7q32.2).https://www.ncbi.nlm.nih.gov/gene/7328

Expr. Heart, adrenal.

E2-20K, GID3, UBC8,UBCH, UBCH2.

The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]

Preferred Names ubiquitin-conjugating enzyme E2 H

Names

(E3-independent) E2 ubiquitin-conjugating enzyme H

E2 ubiquitin-conjugating enzyme H

GID complex subunit 3, UBC8 homolog

ubiquitin carrier protein H

ubiquitin conjugating enzyme E2H

ubiquitin-conjugating enzyme E2-20K

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

ubiquitin-conjugating enzyme E2H (homologous to yeast UBC8)

ubiquitin-protein ligase H

• Kromosomi 8

(19) UBE2V2, (8q11.21), https://www.ncbi.nlm.nih.gov/gene/7336

Exor. Brain, adrenal.

DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2.

Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]

Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes. https://www.ncbi.nlm.nih.gov/pubmed/9199207/

Preferred Names

ubiquitin-conjugating enzyme E2 variant 2

Names

1 alpha,25-dihydroxyvitamin D3-inducible

DDVit 1

MMS2 homolog

enterocyte differentiation promoting factor

enterocyte differentiation-associated factor 1

enterocyte differentiation-associated factor EDAF-1

enterocyte differentiation-promoting factor 1

methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of

vitamin D3-inducible protein

(20) UBE2W, (8q21.11). https://www.ncbi.nlm.nih.gov/gene/55284

Expr. Brain, thyroid.

UBC-16, UBC16.

This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Preferred Names ubiquitin-conjugating enzyme E2 W

Names

E2 ubiquitin-conjugating enzyme W

N-terminal E2 ubiquitin-conjugating enzyme

N-terminus-conjugating E2

ubiquitin carrier protein W

ubiquitin conjugating enzyme E2 W (putative)

ubiquitin conjugating enzyme E2W (putative)

ubiquitin-conjugating enzyme 16

ubiquitin-conjugating enzyme 2W

ubiquitin-protein ligase W

TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.

https://www.ncbi.nlm.nih.gov/pubmed/26101372/

• Kromosomi 9

(21) UBE2R2, (9p13.3). https://www.ncbi.nlm.nih.gov/gene/54926

Expr. Testis, endometrium.

UBC3B; CDC34B; E2-CDC34B

Summary Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]

Preferred Names ubiquitin-conjugating enzyme E2 R2

Names E2 ubiquitin-conjugating enzyme R2

ubiquitin carrier protein R2

ubiquitin conjugating enzyme E2R 2

ubiquitin-conjugating enzyme E2-CDC34B

ubiquitin-conjugating enzyme UBC3B

ubiquitin-protein ligase R2

https://www.ncbi.nlm.nih.gov/pubmed/12037680/

• Kromosomi 10

(22) UBE2D1, (10q21.1). https://www.ncbi.nlm.nih.gov/gene/7321

Expr. Bone marrow, appendix.

E2(17)KB1, SFT,UBC4/5, UBCH5, UBCH5A.

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

SMURF/UBE2D1 complex. https://www.ncbi.nlm.nih.gov/pubmed/24709419

Preferred Names

ubiquitin-conjugating enzyme E2 D1

Names

(E3-independent) E2 ubiquitin-conjugating enzyme D1

E2 ubiquitin-conjugating enzyme D1

UBC4/5 homolog

stimulator of Fe transport

ubiquitin carrier protein D1

ubiquitin conjugating enzyme E2D 1

ubiquitin-conjugating enzyme E2(17)KB 1

ubiquitin-conjugating enzyme E2-17 kDa 1

ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)

ubiquitin-protein ligase D1

• Kromosomi 11

(23) UBE2L6 , (11q12.1). https://www.ncbi.nlm.nih.gov/gene/9246

Expr. Spleen, lymphnode

RIG-B, UBCH8

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein.

Preferred Names ubiquitin/ISG15-conjugating enzyme E2 L6

Names

E2 ubiquitin-conjugating enzyme L6

retinoic acid induced gene B protein

ubiquitin carrier protein L6

ubiquitin conjugating enzyme E2L 6

ubiquitin-protein ligase L6

• Kromosomi 12

(24) UBE2N, (12q22).https://www.ncbi.nlm.nih.gov/gene/7334

HEL-S-71,UBC13, UBCHBEN, UBC13, UbcH-ben, UbcH13.

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]

Together with Riplet, Ube2D3 promotes covalent conjugation of polyubiquitin chains to RIG-I, while Ube2N preferentially facilitates production of unanchored chains. In the presence of these chains, RIG-I induces MAVS aggregation directly on the mitochondria. Data thus reveal two essential mechanisms underlying the activation of RIG-I and MAVS for triggering innate immune signaling in response to viral infection in cells.

Preferred Names ubiquitin-conjugating enzyme E2 N

Names

E2 ubiquitin-conjugating enzyme N

bendless-like ubiquitin conjugating enzyme

epididymis secretory protein Li 71

ubiquitin carrier protein N

ubiquitin conjugating enzyme E2N

ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)

ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13)

ubiquitin-protein ligase N

yeast UBC13 homolog

• Kromosomi 15

(25) UBE2Q2, (15q24.2), https://www.ncbi.nlm.nih.gov/gene/92912

Expr. Thyroid, prostate.

Preferred Names ubiquitin-conjugating enzyme E2 Q2

Names

E2 ubiquitin-conjugating enzyme Q2

ubiquitin carrier protein Q2

ubiquitin conjugating enzyme E2Q family member 2

ubiquitin-protein ligase Q2

https://www.ncbi.nlm.nih.gov/pubmed/22642244/the newly characterized human gene, UBE2Q2, may have implications for the pathogenesis of ALL and could be used for molecular diagnosis purposes in the future.

In the 21 breast cancer cases investigated, a high increase in UBE2Q2 expression was found in 8 breast cancers (38.1%), a moderately increased UBE2Q2 expression was observed in 7 cases (33.3%), and no sig. changes were detected in 6 cases (28.6%).

• Kromosomi 16

(26) UBE2I, (16p13.3). https://www.ncbi.nlm.nih.gov/gene/7329

Expr. Ovary, endometrium.

P18, UBC9, C358B7.1.

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

J Biol Chem. 2016 Feb 19;291(8):3860-70. doi: 10.1074/jbc.M115.680801. Epub 2015 Dec 23.

Characterization and Structural Insights into Selective E1-E2 Interactions in the Human and Plasmodium falciparum SUMO Conjugation Systems.

Preferred Names SUMO-conjugating enzyme UBC9

Names

RING-type E3 SUMO transferase UBC9

SUMO-1-protein ligase

SUMO-protein ligase

ubiquitin carrier protein 9

ubiquitin carrier protein I

ubiquitin conjugating enzyme 9

ubiquitin conjugating enzyme E2I

ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)

ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)

ubiquitin-conjugating enzyme UbcE2A

ubiquitin-like protein SUMO-1 conjugating enzyme

ubiquitin-protein ligase E2I

ubiquitin-protein ligase

• Kromosomi 17

(27) UBE2G1, (17p13.2). https://www.ncbi.nlm.nih.gov/gene/7326

Expr. Oesophagus, lymph node.

E217K, UBC7, UBE2G

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]

https://www.ncbi.nlm.nih.gov/pubmed/12933904

Mol Endocrinol. 2003 Dec;17(12):2603-12. Epub 2003 Aug 21.

Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.

Preferred Names ubiquitin-conjugating enzyme E2 G1

Names

E2 ubiquitin-conjugating enzyme G1

ubiquitin carrier protein G1

ubiquitin conjugating enzyme E2G 1

ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)

ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)

ubiquitin-conjugating enzyme E2G 1 (homologous to C. elegans UBC7)

ubiquitin-protein ligase G1

(28) UBE2O, (17q25.1). https://www.ncbi.nlm.nih.gov/gene/63893

Expr. Brain, testis.

E2-230K.

Preferred Names (E3-independent) E2 ubiquitin-conjugating enzyme

Names

E2/E3 hybrid ubiquitin-protein ligase UBE2O

ubiquitin carrier protein O

ubiquitin conjugating enzyme E2O

ubiquitin-conjugating enzyme E2 of 230 kDa

ubiquitin-conjugating enzyme E2-230K

ubiquitin-protein ligase O

UBE2O is a quality control factor for orphans of multiprotein complexes. Yanagitani K, et al. Science, 2017 Aug 4. PMID 28774922, Free PMC Article

Mol Cell. 2014 May 8;54(3):392-406. doi: 10.1016/j.molcel.2014.03.002. Epub 2014 Apr 3.

Autodeubiquitination protects the tumor suppressor BAP1 (UCHL2) from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.https://www.ncbi.nlm.nih.gov/pubmed/24703950/

monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O and SMAD6 cooperated in the regulation of BMP7-induced adipogenesis

(29) UBE2Z, (17q21.32). https://www.ncbi.nlm.nih.gov/gene/65264

HOYS7, USE1

Expr. Thyroid, brain.

Preferred Names

ubiquitin-conjugating enzyme E2 Z

Names

E2 ubiquitin-conjugating enzyme Z

UBA6-specific enzyme E2

uba6-specific E2 conjugating enzyme 1

ubiquitin carrier protein Z

ubiquitin conjugating enzyme E2Z

ubiquitin-protein ligase Z

This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]

https://www.ncbi.nlm.nih.gov/pubmed/28376205/ Conclusions:

USE1 proteins are frequently overexpressed in lung cancer, and missense mutations in USE1 prolong the half-life of the protein, promoting tumor formation. Our findings reveal novel roles for USE1 in lung cancer and the possible use of USE1 as a novel biomarker and therapeutic target for lung cancer treatment.

• Kromosomi 19

(30) UBE2M, (19q13.43). https://www.ncbi.nlm.nih.gov/gene/9040

UBC-RS2, UBC12, hUbc12.

Expr. Brain, testis.

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]

Preferred Names NEDD8-conjugating enzyme Ubc12

Names

NEDD8 carrier protein

NEDD8 protein ligase

epididymis secretory sperm binding protein

ubiquitin carrier protein M

ubiquitin conjugating enzyme E2M

ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)

ubiquitin-protein ligase M

yeast UBC12 homolog

https://www.ncbi.nlm.nih.gov/pubmed/25025768/. .. UBE2M is required to maintain genome integrity by activating multiple Cullin ligases throughout the cell cycle.

(31) UBE2R1 (19p13.3). https://www.ncbi.nlm.nih.gov/gene/997

CDC34, E2-CDC34, UBC3, UBCH3.

Expr. Testis, placenta.

This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]

Cell cycle regulation by the ubiquitin pathway. Pagano M. FASEB J, 1997 Nov. PMID 9367342

Preferred Names ubiquitin-conjugating enzyme E2 R1

Names (E3-independent) E2 ubiquitin-conjugating enzyme R1

E2 ubiquitin-conjugating enzyme R1

cell division cycle 34 homolog

ubiquitin carrier protein

ubiquitin-conjugating enzyme E2-32 KDA complementing

ubiquitin-conjugating enzyme E2-CDC34

ubiquitin-protein ligase R1

(32) UBE2S, (19q13.42). https://www.ncbi.nlm.nih.gov/gene/27338

Expr. Testis, bone marrow.

E2-EPF, E2EPF, EPF5.

This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

https://www.ncbi.nlm.nih.gov/pubmed/24813613/ ;

Preferred Names ubiquitin-conjugating enzyme E2 S

Names E2 ubiquitin-conjugating enzyme S

E2-EPF5

ubiquitin carrier protein S

ubiquitin conjugating enzyme E2S

ubiquitin-conjugating enzyme E2-24 kD

ubiquitin-conjugating enzyme E2-24 kDa

ubiquitin-conjugating enzyme E2-EPF5

ubiquitin-protein ligase S

RNF8- and Ube2S-dependent Lys11-linkage ubiquitin conjugation plays an important role in regulating DNA damage-induced transcriptional silencing, distinct from the role of Lys63-linkage ubiquitin in the recruitment of DNA damage repair proteins 53BP1 and BRCA1.

Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system.

• Kromosomi 20

(33) UBE2C, (20q13.12). https://www.ncbi.nlm.nih.gov/gene/11065

UBCH10, dJ44753.2.

The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]

Preferred Names ubiquitin-conjugating enzyme E2 C

Names (E3-independent) E2 ubiquitin-conjugating enzyme C

E2 ubiquitin-conjugating enzyme C

cyclin-selective ubiquitin carrier protein

mitotic-specific ubiquitin-conjugating enzyme

ubiquitin conjugating enzyme E2C

ubiquitin-protein ligase C

(34) UBE2V1, (20q13.15). https://www.ncbi.nlm.nih.gov/gene/7335

CIR, CROC-1, CROC1, UBE2V, UEV-1, UEV1, UEV1A.

Expr. Brain, placenta.

Preferred Names ubiquitin-conjugating enzyme E2 variant 1

Names DNA-binding protein

TRAF6-regulated IKK activator 1 beta Uev1A

The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]

Kromosomi 21

(35) UBE2G2, (21q22.3). https://www.ncbi.nlm.nih.gov/gene/7327

UBC7

Expr. Spleen, appendix.

The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Preferred Names ubiquitin-conjugating enzyme E2 G2

Names E2 ubiquitin-conjugating enzyme G2

ubiquitin carrier protein G2

ubiquitin conjugating enzyme 7

ubiquitin conjugating enzyme G2

ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)

ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7)

ubiquitin-protein ligase G2

https://www.ncbi.nlm.nih.gov/pubmed/16582478

The human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7) is involved in protein degradation, including a process known as endoplasmic reticulum-associated degradation (ERAD). The crystal structure of human UBE2G2/UBC7 was solved at 2.56 angstroms resolution..

• Kromosomi 22

(36) UBE2L3, (22q11.21). https://www.ncbi.nlm.nih.gov/gene/7332

E2-F1; L-UBC; UBCH7; UbcM4

Expr. Brain, urinary bladder.

Preferred Names ubiquitin-conjugating enzyme E2 L3

Names E2 ubiquitin-conjugating enzyme L3

ubiquitin carrier protein L3

ubiquitin conjugating enzyme E2L 3

ubiquitin-conjugating enzyme E2-F1

ubiquitin-conjugating enzyme UBCH7

ubiquitin-protein ligase L3

This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

https://www.ncbi.nlm.nih.gov/pubmed/25422456 UbcH7 regulates 53BP1 stability and DSB repair.

• Kromosomi X

(37) UBE2A, (Xq24) https://www.ncbi.nlm.nih.gov/gene/7319

HHR6A, MRXS30, MRXSN, RAD6A, UBC2.

Expr. Placenta, colon.

Preferred Names ubiquitin-conjugating enzyme E2 A

Names E2 ubiquitin-conjugating enzyme A

RAD6 homolog A

ubiquitin carrier protein A

ubiquitin-conjugating enzyme E2A

ubiquitin-protein ligase A

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

https://www.ncbi.nlm.nih.gov/pubmed/25384975

(38) UBE2NL, (Xq27.3). https://www.ncbi.nlm.nih.gov/gene/389898

Li174.

Preferred Names

putative ubiquitin-conjugating enzyme E2 N-like

Names

epididymis tissue protein Li 174

ubiquitin conjugating enzyme E2N-like

This gene is intronless and encodes a member of the ubiquitin-conjugating enzyme family. The protein product is 91% identical to ubiquitin-conjugating enzyme E2N, a multi-exon gene product. This locus represents a polymorphic pseudogene, where some individuals contain an allele that can encode a full-length protein, while others have a non-functional allele containing a premature stop codon (reference SNP rs237520) that truncates the coding sequence. [provided by RefSeq, Jun 2014]

15.5. 2019 Muistiin 38 UBE2 Ubikitiini konjugaasia E2.