RRP9. Ribosomaalisen pienen alayksikön SSU prosessomin komponenti . Essentielli 18S rRNA prosessoinnissa

RRP9 (3p21.2)
SARS2 viruksen N- proteiinin interaktioproteiini.
https://www.genecards.org/cgi-bin/carddisp.pl?gene=RRP9&keywords=RRP9

Aliases for RRP9 Gene

• Ribosomal RNA Processing 9, U3 Small Nucleolar RNA Binding Protein ^{2 3 5}
• U3 Small Nucleolar Ribonucleoprotein-Associated 55 KDa Protein ^{3 4}
• RNA, U3 Small Nucleolar Interacting Protein 2 ^{2 3}
• U3 Small Nucleolar RNA-Interacting Protein 2 ^{3 4}
• RRP9 Homolog ^{3 4}
• RNU3IP2 ^{3 4}

• U3-55K ^{3 4}
• Ribosomal RNA Processing 9, Small Subunit (SSU) Processome Component, Homolog (Yeast) ²
• Ribosomal RNA Processing 9, Small Subunit (SSU) Processome Component, Homolog ³
• RRP9, Small Subunit (SSU) Processome Component, Homolog ³
• U3 SnoRNP-Associated 55-KDa Protein ³
• U3 SnoRNP-Associated 55 KDa Protein ⁴
• U355K ⁴

Entrez Gene Summary for RRP9 Gene
This gene encodes a member of the WD-repeat protein family. The encoded protein is a component of the nucleolar small nuclear ribonucleoprotein particle (snoRNP) and is essential for 18s rRNA processing during ribosome synthesis. It contains seven WD domains required for nucleolar localization and specific interaction with the U3 small nucleolar RNA (U3 snoRNA). [provided by RefSeq, Oct 2012]

GeneCards Summary for RRP9 Gene

RRP9 (Ribosomal RNA Processing 9, U3 Small Nucleolar RNA Binding Protein) is a Protein Coding gene. Diseases associated with RRP9 include Diffuse Scleroderma and Hypertrophy Of Breast. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include U3 snoRNA binding.

UniProtKB/Swiss-Prot Summary for RRP9 Gene

Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA).  U3IP2_HUMAN,O43818

Protein attributes for RRP9 Gene

Size: 475 amino acids Molecular mass: 51841 Da . Quaternary structure: Interacts specifically with the U3 small nucleolar RNA (U3 snoRNA) (PubMed:10982864, PubMed:12381732). Binds a sub-fragment of the U3 snoRNA surrounding the B/C motif (3UBC) (PubMed:10982864, PubMed:12381732). This association with the U3BC RNA is dependent on the binding of a protein called 15.5K to the box B/C motif (PubMed:10982864, PubMed:12381732). The association of the protein with the U3BC RNA was found to be also dependent on a conserved RNA structure that flanks the box B/C motif (PubMed:10982864, PubMed:12381732).

Post-translational modifications for RRP9 Gene

• Acetylation at Lys-12 and Lys-25 by KAT2B/PCAF under stress impairs pre-rRNA processing (PubMed:26867678). Deacetylation by SIRT7 enhances RRP9-binding to U3 snoRNA, which is a prerequisite for pre-rRNA processing (PubMed:26867678).
  • O43818-U3IP2_HUMAN
• Ubiquitination at Lys129
  • NX_O43818 (NX_O43818-1)
• Modification sites at PhosphoSitePlus
  • O43818