Katson lisätietoa näistä proteiineista, koska ne kuuluvat 332 SARS2 viruksen proteiini-proteiini interaktioproteiinein (ppi) joukkoon.
LARP1, interaktioproteiini SARS2 N.
LARP7, interaktiopoteiini SARS2 nsp8.
LARP4B interaktioåproteiini SARS2 nsp12
LARP tarkoittaa La Ribonucleoprotein domain family member ( 1, 2 , ... etc)
- LARP1, (5q33.2) , La related protein 1
Aliases for LARP1 Gene
GeneCards Summary for LARP1 Gene
LARP1 (La Ribonucleoprotein 1, Translational Regulator) is a Protein Coding gene.
Diseases associated with LARP1 include Hepatocellular Carcinoma.
Among its related pathways are Translational Control.
Gene Ontology (GO) annotations related to this gene include translation initiation factor binding.
An important paralog of this gene is LARP1B.
UniProtKB/Swiss-Prot Summary for LARP1 Gene
RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122).
RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122).
Interacts on the one
hand with the 3' poly-A tails that are present in all mRNA molecules,
and on the other hand with the 7-methylguanosine cap structure of mRNAs
containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present
in mRNAs encoding ribosomal proteins and several components of the
translation machinery (PubMed:23711370, PubMed:25940091,
PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136).
The
interaction with the 5' end of mRNAs containing a 5'TOP motif leads to
translational repression by preventing the binding of EIF4G1
(PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136).
When mTORC1 is activated, LARP1 is phosphorylated and dissociates from
the 5' untranslated region (UTR) of mRNA (PubMed:25940091,
PubMed:28650797).
Does not prevent binding of EIF4G1 to mRNAs that lack a
5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome
subunit and with ribosomes, both monosomes and polysomes
(PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543).
Under normal nutrient availability, interacts primarily with the 3'
untranslated region (UTR) of mRNAs encoding ribosomal proteins and
increases protein synthesis (PubMed:23711370, PubMed:28650797).
Associates with actively translating ribosomes and stimulates
translation of mRNAs containing a 5'TOP motif, thereby regulating
protein synthesis, and as a consequence, cell growth and proliferation
(PubMed:20430826, PubMed:24532714).
Stabilizes mRNAs species with a
5'TOP motif, which is required to prevent apoptosis (PubMed:20430826,
PubMed:23711370, PubMed:25940091, PubMed:28673543 LARP1_HUMAN,Q6PKG0 (Microbial infection) Positively regulates the replication of dengue virus (DENV). LARP1_HUMAN,Q6PKG0.
Protein attributes for LARP1 Gene
Size: 1096 amino acids. Molecular mass: 123510 Da Quaternary structure:Interacts with PABPC1/PABP (PubMed:20430826,
PubMed:24532714, PubMed:25940091, PubMed:23711370, PubMed:28650797).
Interacts with EIF4A1 (PubMed:24532714). Interacts with RPTOR
(PubMed:24532714, PubMed:25940091, PubMed:28650797). Recruited to the
active mTORC1 complex via interaction with RPTOR (PubMed:25940091,
PubMed:28650797). Inhibition of mTORC1 activity strongly reduces
interaction with RPTOR and the mTORC1 complex (PubMed:25940091,
PubMed:28650797). Identified in a complex with mRNA, PABPC1**, EIF4E* and
EIF4G1 (PubMed:20430826, PubMed:28650797). Found in a complex with
PABPC1 and SHFL (PubMed:26735137).
Mainittu PABPC1 **(8q22.3) , (poly A binding protein, cytoplasmic 1, RNA binding motif containing ) tekee interaktion SARS2 N-proteiinin kanssa.
- LARP4B, (10p15.3), La-Related Protein 4B
Aliases for LARP4B Gene
LARP4B Gene. This gene encodes a member of an evolutionarily
conserved protein family implicated in RNA metabolism and translation.
Members of this family are characterized by the presence of an La motif,
which is often located adjacent to one or more RNA recognition motifs
(RRM). Together, the two motifs constitute the functional region of the
protein and enable its interaction with the RNA substrate. This protein
family is divided into five sub-families: the genuine La proteins and
four La-related protein (LARP) sub-families. The protein encoded by this
gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may
play a stimulatory role in translation. [provided by RefSeq, Oct 2012] GeneCards Summary for LARP4B Gene
LARP4B (La Ribonucleoprotein 4B) is a Protein Coding gene.
An important paralog of this gene is LARP4. UniProtKB/Swiss-Prot Summary for LARP4B Gene Stimulates mRNA translation. LAR4B_HUMAN,Q92615
Protein attributes for LARP4B Gene Size: 738 amino acids Molecular mass: 80552 Da
Quaternary structure: Interacts with PABPC1 *(PubMed:20573744,
Ref.23). Interacts with RACK1 (PubMed:20573744). Associates with
polysomes via the 40S ribosomal subunit (PubMed:20573744).
- LARP7, (4q25), La-related protein 7
Aliases for LARP7 Gene
This gene encodes a protein which is found in
the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex
inhibits a cyclin-dependent kinase, positive transcription elongation
factor b, which is required for paused RNA polymerase II at a promoter
to begin transcription elongation. A pseudogene of this gene is located
on chromosome 3. Alternative splicing results in multiple transcript
variants. [provided by RefSeq, May 2012]
GeneCards Summary for LARP7 gene (La Ribonucleoprotein 7, Transcriptional Regulator) is a Protein Coding gene.
Diseases associated with LARP7 include Alazami Syndrome and Autosomal Dominant Non-Syndromic Intellectual Disability 27.
Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.
An important paralog of this gene is SSB.
UniProtKB/Swiss-Prot Summary for LARP7 Gene: Negative transcriptional regulator of
polymerase II genes, acting by means of the 7SK RNP system. Within the
7SK RNP complex, the positive transcription elongation factor b (P-TEFb)
is sequestered in an inactive form, preventing RNA polymerase II
phosphorylation and subsequent transcriptional elongation. LARP7_HUMAN,Q4G0J3
https://en.wikipedia.org/wiki/7SK_RNA
https://en.wikipedia.org/wiki/7SK_RNA
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