RPL11 (1p36.11), 60S ribosomal protein L11
Aliases for RPL11 Gene
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]
Aliases for RPL11 Gene
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]
GeneCards Summary for RPL11 Gene
RPL11 (Ribosomal Protein L11) is a Protein Coding gene.
Diseases associated with RPL11 include Diamond-Blackfan Anemia 7 and Diamond-Blackfan Anemia.
Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication.
Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.
UniProtKB/Swiss-Prot Summary for RPL11 Gene
Component of the ribosome, a large
ribonucleoprotein complex responsible for the synthesis of proteins in
the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs)
and translates the encoded message by selecting cognate
aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU)
contains the ribosomal catalytic site termed the peptidyl transferase
center (PTC), which catalyzes the formation of peptide bonds, thereby
polymerizing the amino acids delivered by tRNAs into a polypeptide
chain.
The nascent polypeptides leave the ribosome through a tunnel in
the LSU and interact with protein factors that function in enzymatic
processing, targeting, and the membrane insertion of nascent chains at
the exit of the ribosomal tunnel. As part of the 5S RNP/5S
ribonucleoprotein particle it is an essential component of the LSU,
required for its formation and the maturation of rRNAs (PubMed:19061985,
PubMed:12962325, PubMed:24120868). It also couples ribosome biogenesis
to p53/TP53 activation. As part of the 5S RNP it accumulates in the
nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed,
mediating the stabilization and the activation of TP53
(PubMed:24120868). Promotes nucleolar location of PML (By similarity) RL11_HUMAN,P62913
Protein attributes for RPL11 Gene
Size:178 amino acids Molecular mass: 20252 Da
Quaternary structure:
- Component of the large ribosomal subunit (LSU). Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11 (PubMed:24120868). Interacts with PML (By similarity). Interacts with MDM2; negatively regulates MDM2-mediated TP53 ubiquitination and degradation (PubMed:24120868). Interacts with NOP53; retains RPL11 into the nucleolus (PubMed:24556985, PubMed:27829214).
RIBOSOME structure: https://www.biologydiscussion.com/proteins/protein-synthesis/role-of-ribosomes-in-protein-synthesis-with-diagram/16477
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