ZNHIT sinkkisormiproteiinit. Kuusi(1-6) ZNHIT- geeniä. Niissä ei ole transkiptiotekijöitä. (Vappuaattokaranteenia pandemian päivinä)

•  ZNHIT1, (7q22.1) CG1L, ZNFN4A1

 https://www.ncbi.nlm.nih.gov/gene/?term=ZNHIT

Preferred Names

zinc finger HIT domain-containing protein 1

Names

H_DJ0747G18.14

cyclin-G1-binding protein 1

p18 Hamlet

p18Hamlet

putative cyclin G1 interacting protein

zinc finger protein subfamily 4A member 1

zinc finger protein, subfamily 4A (HIT domain containing), member 1

zinc finger, HIT domain containing 1

zinc finger, HIT type 1

1. Low ZNHIT1 expression is associated with breast cancer.
2. Study reports that p18(Hamlet) can also mediate the cell cycle arrest induced in response to gamma-irradiation, by participating in the p53-dependent upregulation of the cell cycle inhibitor p21(Cip1) (CDKN1A).
3. p18(Hamlet) is a new cell-fate regulator that links the p38 MAPK and p53 pathways and contributes to the establishment of p53-regulated stress responses.

• ZNHIT2, (11q13.1),  C11orf5, FON

HIT zinc finger

This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) that specifically interact with the ligand binding domain of the thyroid receptor.
https://www.ncbi.nlm.nih.gov/gene/?term=ZNHIT2 

1. The interaction between RUVBL1/RUVBL2 and the U5 small nuclear ribonucleoprotein is mostly mediated by the previously uncharacterized factor ZNHIT2.
2. The unique three-dimensional structure of the zinc finger HIT domain revealed a novel zinc-binding fold, as a new member of the treble clef domain family

• ZNHIT3 (17q12) , Hit1, PEHO, TRIP3

https://www.ncbi.nlm.nih.gov/gene/9326

Preferred Names

zinc finger HIT domain-containing protein 3

Names

HNF-4a coactivator

TR-interacting protein 3

TRIP-3

thyroid hormone receptor interactor 3

thyroid receptor interacting protein 3

zinc finger, HIT domain containing 3

zinc finger, HIT type 3

1. results suggest that loss-of-function missense mutation of znhit3 underlies PEHO syndrome. Progressive encephalopathy with oedema, hypsarrhythmia, and optic atrophy (PEHO)
2. Results solve the structure of a complex resulting from interaction between protein fragments of human NUFIP1 and its cofactor ZNHIT3, and emphasize their imbrication. Also, it seems that the complexes involving NUFIP1, ZNHIT3, and SNU13 share strong structural similarities between human and yeast, suggesting that the initial steps of the box C/D snoRNP assembly process are conserved among species.
3. Results identify TRIP3 as a novel regulator of PPARgamma-mediated adipocyte differentiation.
4. A high GYPC gene expression is associated with an unfavorable outcome, in contrast, a high TRIP3 gene expression is associated with a favorable outcome in childhood ALL.

• ZNHIT4(2p13.1), INO80,

 HMGA1L4, HMGIYL4, IES2, PAP-1BP, PAPA-1, PAPA1, hIes2
 https://www.ncbi.nlm.nih.gov/gene/?term=ZNHIT4

Preferred Names

INO80 complex subunit B

Names

IES2 homolog

PAP (Pim-1 associated protein) associated protein 1

PAP-1 binding protein

PAP-1-associated protein 1

high mobility group AT-hook 1-like 4

zinc finger HIT domain-containing protein 4

zinc finger, HIT type 4

 Knockdown of INO80 complex subunit B (INO80B; ZNHIT4) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N

1. Susceptibility allele-specific loss of miR-1324-mediated silencing of the INO80B chromatin-assembly complex gene in pre-eclampsia. Oudejans CB, et al. Hum Mol Genet, 2015 Jan 1. PMID 25143393
2. A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase. Kuroda TS, et al. Gene, 2004 Sep 29. PMID 15556297
3. PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions. Miyako K, et al. Mol Endocrinol, 2009 Feb. PMID 19095771, Free PMC Article
4. E2F6 associates with BRG1 in transcriptional regulation. Leung JY, et al. PLoS One, 2012. PMID 23082233, Free PMC Article
5. YY1 functions with INO80 to activate transcription. Cai Y, et al. Nat Struct Mol Biol, 2007 Sep. PMID 17721549

• ZNHIT5,  (1q32.1) DDX59, 

DEAD-box helicase 59

 https://www.ncbi.nlm.nih.gov/gene/?term=ZNHIT5

Preferred Names

probable ATP-dependent RNA helicase DDX59

Names

DEAD (Asp-Glu-Ala-Asp) box polypeptide 59

DEAD box protein 59

zinc finger HIT domain-containing protein 5

• ZNHIT6, (1p22.3), BCD1, C1orf181, NY-BR-75

 https://www.ncbi.nlm.nih.gov/gene/54680

Preferred Names

box C/D snoRNA protein 1

Names

box C/D snoRNA essential 1 homolog

serologically defined breast cancer antigen NY-BR-75

zinc finger HIT domain-containing protein 6

zinc finger, HIT type 6

1. Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control. Bizarro J, et al. J Cell Biol, 2014 Nov 24. PMID 25404746, Free PMC Article
2. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. Scanlan MJ, et al. Cancer Immun, 2001 Mar 30. PMID 12747765
3. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. McKeegan KS, et al. Mol Cell Biol, 2007 Oct. PMID 17636026, Free PMC Article
4. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Armour SM, et al. Mol Cell Biol, 2013 Apr. PMID 23382074, Free PMC Article
5. R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein. Cloutier P, et al. Nat Commun, 2017 May 31. PMID 28561026, Free PMC Article