ZBTB16 , (11q23.2), PLZF, ZNF145, Säädellee AT2 reseptoria

 ZBTB16 (11q23.2),
https://www.ncbi.nlm.nih.gov/protein/NP_001018011.1

Official Full Name

zinc finger and BTB domain containing 16

Also known as

PLZF; ZNF145

Summary

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Expression

Broad expression in fat (RPKM 27.9), ovary (RPKM 22.2) and 19 other tissues See more

Orthologs

mouse all

Preferred Names

zinc finger and BTB domain-containing protein 16

Names

promyelocytic leukaemia zinc finger

zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)

zinc finger protein PLZF

Retrovirus HIV-1 Vif säätää alas  ZBTB16 ilmentymisen T-soluissa, joissa  Vif expressoituu.

Conserved Domains (4) summary

COG5048
Location:448 → 622

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:520 → 540

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:25 → 125

BTB; BTB/POZ domain

cl28033
Location:177 → 327

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  
            Summary: This gene is a member of the Krueppel C2H2-type
            zinc-finger protein family and encodes a zinc finger transcription
            factor that contains nine Kruppel-type zinc finger domains at the
            carboxyl terminus. This protein is located in the nucleus, is
            involved in cell cycle progression, and interacts with a histone
            deacetylase. Specific instances of aberrant gene rearrangement at
            this locus have been associated with acute promyelocytic leukemia
            (APL). Alternate transcriptional splice variants have been
            characterized. [provided by RefSeq, Jul 2008].

ORIGIN      
        1 mdltkmgmiq lqnpshptgl lckanqmrla gtlcdvvimv dsqefhahrt vlactskmfe
       61 ilfhrnsqhy tldflspktf qqileyayta tlqakaedld dllyaaeile ieyleeqclk
      121 mletiqasdd ndteatmadg gaeeeedrka rylknifisk hsseesgyas vagqslpgpm
      181 vdqspsvsts fglsamsptk aavdslmtig qsllqgtlqp pagpeeptla gggrhpgvae
      241 vktemmqvde vpsqdspgaa essisggmgd kveergkegp gtptrssvit sarelhygre
      301 esaeqvpppa eagqaptgrp ehpapppekh lgiysvlpnh kadavlsmps svtsglhvqp
      361 alavsmdfst yggllpqgfi qrelfsklge lavgmksesr tigeqcsvcg velpdneave
      421 qhrklhsgmk tygcelcgkr fldslrlrmh llahsagaka fvcdqcgaqf skedalethr
      481 qthtgtdmav fcllcgkrfq aqsalqqhme vhagvrsyic secnrtfpsh talkrhlrsh
      541 tgdhpyecef cgscfrdest lkshkrihtg ekpyecngcg kkfslkhqle thyrvhtgek
      601 pfecklchqr srdysamikh lrthngaspy qcticteycp slssmqkhmk ghkpeeippd
      661 wriektylyl cyv
// 

https://www.scienceopen.com/document_file/080cd021-f521-4ae2-a1c4-96859161b4e3/

PubMedCentral/080cd021-f521-4ae2-a1c4-96859161b4e3.pdf

• “Guimond and Gallo-PayetAngiotensin-AT2 receptor and neuronal physiology

  PLZF (11q28.2) ZBTB16 , ZNF145. 

  Association between the AT2 receptor and the promyelocytic leukemia zinc finger (PLZF)

   protein has been observed using a yeast two-hybrid system (Senbonmatsu et al., 2003). In CHO 

   cells expressing both PLZF and AT2 receptors, Ang II stimulation induces

   co-localization of PLZF with the AT2 receptor, followed by internalization of the complex.

   This observation is in contrast with other studies observing no internalization of

   the AT2receptor following Ang II stimulation (Hunyady et al., 1994;Hein et al., 1997).

   Since internalization of the receptor was observed only in cells expressing PLZF,

   this could represent a new regulatory pathway of AT2 receptor function, specific only

    to selected cell types. However, beside internalization of AT2 receptor, a recent study

   showed that PLZF  was implicated in neuroprotection in a stroke model (Seidelet al., 2011).

   In this study, the authors  showed that PLZF exerts neuroprotective effect in a model of in

   vitro glutamate toxicity.They also showed that overexpression of PLZF in neuronal cells 

  in culture induced a significant increase in AT2 receptor

   expression, suggesting that PLZF could also be implicated in the regulation of AT2receptor 

  expression.