ZBTB7A (19p13.3), ZBTB7, ZNF857A, FBI-1, FBI-1, TIP21, pokemon

https://www.ncbi.nlm.nih.gov/pubmed/31385585/

Official Symbol

ZBTB7A

Official Full Name

zinc finger and BTB domain containing 7A

Also known as

LRF; FBI1; FBI-1; TIP21; ZBTB7; ZNF857A; pokemon

Expression

Ubiquitous expression in colon (RPKM 8.0), stomach (RPKM 5.5) and 25 other tissues See more

Orthologs mouse all

Preferred Names

zinc finger and BTB domain-containing protein 7A

Names

HIV-1 1st-binding protein 1

HIV-1 inducer of short transcripts binding protein

POK erythroid myeloid ontogenic factor

POZ and Krueppel erythroid myeloid ontogenic factor

TTF-I-interacting peptide 21

factor binding IST protein 1

factor that binds to inducer of short transcripts protein 1

leukemia/lymphoma-related factor, ( LRF)

lymphoma related factor

pokemon 1

zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein

zinc finger protein 857A

  NP_001304919.1  zinc finger and BTB domain-containing protein 7A

ORIGIN      
        1 maggvdgpig ipfpdhssdi lsglneqrtq gllcdvvilv egrefpthrs vlaacsqyfk
       61 klftsgavvd qqnvyeidfv saealtalmd faytatltvs tanvgdilsa arlleipavs
      121 hvcadlldrq ilaadagada gqldlvdqid qrnllrakey leffqsnpmn slppaaaaaa
      181 asfpwsafga sdddldatke avaaavaava agdcngldfy gpgppaerpp tgdgdegdsn
      241 pglwperded aptgglfppp vappaatqng hygrggeeea aslseaapep gdspgflsga
      301 aegedgdgpd vdglaastll qqmmssvgra gaaagdsdee sraddkgvmd yylkyfsgah
      361 dgdvypawsq kvekkiraka fqkcpicekv iqgagklprh irthtgekpy ecnickvrft
      421 rqdklkvhmr khtgekpylc qqcgaafahn ydlknhmrvh tglrpyqcds ccktfvrsdh
      481 lhrhlkkdgc ngvpsrrgrk prvrggapdp spgatatpga paqpsspdar rngqekhfkd
      541 edededvasp dglgrlnvag aggggdsggg pgaatdgnft agla

 

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Conserved Domains (3) summary

sd00017
Location:412 → 432

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:24 → 131

BTB; BTB/POZ domain

pfam13465
Location:425 → 449

zf-H2C2_2; Zinc-finger double domain

Related articles in PubMed

1. ZBTB7A promotes migration, invasion and metastasis of human breast cancer cells through NF-κB-induced epithelial-mesenchymal transition in vitro and in vivo. Mao A, et al. J Biochem, 2019 Dec 1. PMID 31385585
2. LRF acts as an activator and repressor of the human β-like globin gene transcription in a developmental stage dependent manner. Kang J, et al. Biochem Cell Biol, 2019 Aug. PMID 30427207
3. Impact of ZBTB7A hypomethylation and expression patterns on treatment response to hydroxyurea. Chondrou V, et al. Hum Genomics, 2018 Oct 1. PMID 30285874, Free PMC Article
4. Expression of Zinc Finger and BTB Domain-containing 7A in Colorectal Carcinoma. Joo JW, et al. Anticancer Res, 2018 May. PMID 29715100
5. Stable knockdown of ZBTB7A promotes cell proliferation and progression in nasopharyngeal carcinoma. Liu F, et al. Tumori, 2018 Jan-Feb. PMID 29699474

See all (109) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. miR-137 was identified to negatively regulate the expression of ZBTB7, and its abundance is inversely correlated with that of ZBTB7 in renal carcinoma specimens and cell lines.
2. ZBTB7A had a positive association with NR_047538.
3. The high expression of ZBTB7A may promote cell migration, invasion and tumour metastasis, which may be related to EMT events by regulating NF-kappaB.
4. The results indicate that LRF may act as an activator and repressor of the human beta-like globin gene transcription in a manner dependent on developmental stage.
5. ZBTB7A transcriptionally regulates ER-alpha expression in ER-alpha-positive breast cancer cell lines by binding to the ESR1 promoter leading to increased transcription of ER-alpha.
6. Direct epigenetic repression of the transcription-repressive regulators NCOR2 and ZBTB7A by the histone reader protein HP1gamma leads to activation of protumorigenic genes in lung adenocarcinoma.
7. Some forms of hereditary persistence of fetal hemoglobin, a rare benign condition where individuals express the gamma-globin gene throughout adulthood, are caused by point mutations in the gamma-globin gene promoter at regions residing ~115 and 200 bp upstream of the transcription start site. We found that the major fetal globin gene repressors BCL11A and ZBTB7A directly bound to the sites at -115 and -200 bp, respecti...
8. ZBTB7 was upregulated in colorectal cancer and promoted cancer progression.ZBTB7 mediated 5fluorouracil drug resistance in the colorectal cancer cells through NFkappaB signaling.
9. This is one of the very first pharmacoepigenomic studies indicating that the hypomethylation of ZBTB7A during hydroxyurea (HU) treatment enhances the LRF expression, which by its turn suppresses the HbF resumption in the HU non-responders
10. ASXL2 and ZBTB7A mutations were frequently identified in Japanese AML patients with t(8;21), but not in those with inv(16). Further analysis is required to clarify the detailed biological mechanism of AE9a regulation of the cohesin complex.

Protein	Gene	Interaction	Pubs
Tat	tat	Binding of FBI-1 to HIV-1 Tat is mediated by the zinc finger (ZF) domain of FBI-1 (amino acids 377-584) and is diminished by point mutations in Tat at amino acids 18, 30, and 31	PubMed
	tat	FBI-1 is a cellular POZ-domain-containing protein that binds to the HIV-1 LTR and Tat protein and specifically stimulates Tat activity