ZBTB3 (11q12.3)

  ZBTB3  (11q12.3) https://www.ncbi.nlm.nih.gov/gene/79842

1. NM_001363108.2 → NP_001350037.1  zinc finger and BTB domain-containing protein 3
   
   Status: VALIDATED

   Source sequence(s)

   AP001160

   Conserved Domains (4) summary

   sd00017
   Location:424 → 444

   ZF_C2H2; C2H2 Zn finger [structural motif]

   pfam00651
   Location:14 → 115

   BTB; BTB/POZ domain

   pfam13465
   Location:437 → 461

   zf-H2C2_2; Zinc-finger double domain

   cl26464
   Location:173 → 401

   Atrophin-1; Atrophin-1 family
   

   Atrophin-1 family

   Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity

1. Zinc finger and BTB domain-containing protein 3 is essential for the growth of cancer cells. Lim JH. BMB Rep, 2014 Jul. PMID 24856827, Free PMC Article
2. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. Varier RA, et al. J Biol Chem, 2016 Apr 1. PMID 26841866, Free PMC Article
3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. Chen Y, et al. Mol Cell Proteomics, 2013 Oct. PMID 23824909, Free PMC Article
4. Functional proteomics mapping of a human signaling pathway. Colland F, et al. Genome Res, 2004 Jul. PMID 15231748, Free PMC Article
5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

See all (12) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

MB Rep. 2014 Jul;47(7):405-10.
Zinc finger and BTB domain-containing protein 3 is essential for the growth of cancer cells.

Lim JH¹.

Author information

Abstract

ZBTB3 belongs to the Zinc finger and BTB/POZ domain containing transcription factor family; however, its biological role has rarely been studied. We demonstrate for the first time, to our knowledge, that ZBTB3 is an essential factor for cancer cell growth via the regulation of the ROS detoxification pathway. Suppression of ZBTB3 using two different short hairpin RNAs in human melanoma, lung carcinoma, and breast carcinoma results in diminished cell growth. In addition, we found that suppression of ZBTB3 activates a caspase cascade, including caspase-9, -3, and PARP leading to cellular apoptosis, resulting from failed ROS detoxification. We identified that ZBTB3 plays an important role in the gene expression of ROS detoxification enzymes. Our results reveal that ZBTB3 may play a critical role in cancer cell growth via the ROS detoxification system. Therefore, therapeutic strategies that target ZBTB3 could be used in selective cancer treatments.

PMID:

24856827

PMCID:

PMC4163853

DOI:

10.5483/bmbrep.2014.47.7.075

[Indexed for MEDLINE]

Free PMC Article