ZBTB4 (17p13.1), KAISO-L1, ZNF903.Genomin stabiilisuus, epigeneettinen säätö

https://www.ncbi.nlm.nih.gov/gene/57659

Official Symbol

ZBTB4

Official Full Name

zinc finger and BTB domain containing 4

Also known as

ZNF903; KAISO-L1

Expression

Ubiquitous expression in ovary (RPKM 24.8), thyroid (RPKM 20.6) and 25 other tissues See more

Orthologs mouse all

Preferred Names

zinc finger and BTB domain-containing protein 4

Names

KAISO-like zinc finger protein 1

NP_001122305.1  zinc finger and BTB domain-containing protein 4

Conserved Domains (5) summary

smart00225
Location:31 → 62

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:311 → 331

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:20 → 62

BTB; BTB/POZ domain

pfam13465
Location:323 → 347

zf-H2C2_2; Zinc-finger double domain

pfam13913
Location:235 → 257

zf-C2HC_2; zinc-finger of a C2HC-type

Related articles in PubMed

1. Tumor suppressive ZBTB4 inhibits cell growth by regulating cell cycle progression and apoptosis in Ewing sarcoma. Yu Y, et al. Biomed Pharmacother, 2018 Apr. PMID 29425745
2. Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease. Blue EE, et al. Genes Brain Behav, 2018 Jul. PMID 29045054, Free PMC Article
3. Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer. Kim K, et al. Oncogene, 2012 Feb 23. PMID 21765466, Free PMC Article
4. MicroRNA-301b-3p accelerates the growth of gastric cancer cells by targeting zinc finger and BTB domain containing 4. Fan H, et al. Pathol Res Pract, 2019 Nov. PMID 31585814
5. Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis. Roussel-Gervais A, et al. Cancer Res, 2017 Jan 1. PMID 27815388

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. miR-301-3p was highly expressed in gastric cancer contributed to tumor progression via attenuating ZBTB4
2. Results show association between AAO of AD and both ZBTB4 and NCSTN. ZBTB4 is a transcriptional repressor that regulates the cell cycle, including the apoptotic response to amyloid beta, while NCSTN is part of the gamma secretase complex, known to influence amyloid beta production.
3. In vitro, ZBTB4 overexpression inhibited cell proliferation, and induced cell cycle arrest at G1 phase and apoptosis in SK-ES-1 and RD-ES cells.
4. Our results establish the epigenetic regulator ZBTB4 as an essential component in maintaining genomic stability
5. Thus, EZH2 is reciprocally regulated by a novel signaling network consisting of Sp proteins, oncogenic miRs and ZBTB4, and modulation of this gene network is a novel therapeutic approach for treatment of breast cancer and possibly other cancers.
6. ZBTB4 functions as a novel tumor-suppressor gene with prognostic significance for breast cancer survival
7. the human zinc-finger protein ZBTB4 binds methylated DNA in a sequence-specific manner. https://www.ncbi.nlm.nih.gov/pubmed/19448668
8. Results show that overexpressing HIPK2 causes the degradation of ZBTB4, whereas overexpressing a kinase-deficient mutant of HIPK2 has no effect.
9. These data suggest that Zbtb4 is a critical determinant of the cellular response to p53 activation and reinforce the notion that p21Cip1 can provide an essential survival signal in cells with activated p53.
10. ZBTB4 binds methylated methylated CpGs in vitro and in vivo and represses transcrption.