ZBTB35 (5p12), ZNF131, pHZ-10, vaimentaa estrogeenisignalointia ER alfa-dimerisaatiota estäen

  ZBTB35( 5p12), ZNF131, pHZ-10. https://www.ncbi.nlm.nih.gov/gene/7690

Official Symbol

ZNF131

Official Full Name

zinc finger protein 131

Also known as

ZBTB35; pHZ-10

Expression

Ubiquitous expression in testis (RPKM 10.2), bone marrow (RPKM 5.2) and 25 other tissues See more

Orthologs mouse all

 

1. NM_001297548.2 → NP_001284477.1  zinc finger protein 131 isoform 1
   See identical proteins and their annotated locations for NP_001284477.1
   
   Status: VALIDATED

   Description

   Transcript Variant: This variant (1) encodes the longest isoform (1).

   Conserved Domains (6) summary

   smart00225
   Location:35 → 122

   BTB; Broad-Complex, Tramtrack and Bric a brac

   COG5048
   Location:262 → 444

   COG5048; FOG: Zn-finger [General function prediction only]

   sd00017
   Location:290 → 311

   ZF_C2H2; C2H2 Zn finger [structural motif]

   sd00019
   Location:422 → 439

   ZF_C2H2; C2H2 Zn finger [structural motif]

   pfam00651
   Location:24 → 122

   BTB; BTB/POZ domain

   pfam13465
   Location:342 → 367

   zf-H2C2_2; Zinc-finger double domain

2.  
3. Ref. 

1. High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling. Han X, et al. BMC Genomics, 2008 Oct 11. PMID 18847501, Free PMC Article
2. ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5. Ding Y, et al. Oncotarget, 2017 Jul 25. PMID 28596487, Free PMC Article
3. Zinc finger protein 131 inhibits estrogen signaling by suppressing estrogen receptor α homo-dimerization. Oh Y, et al. Biochem Biophys Res Commun, 2013 Jan 4. PMID 23159625
4. The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus. Trappe R, et al. Biochem Biophys Res Commun, 2002 Aug 16. PMID 12163020
5. Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling. Oh Y, et al. J Biol Chem, 2012 May 18. PMID 22467880, Free PMC Article .. Here, we identify ZNF131 as a target for SUMO modification and as a substrate for the SUMO E3 ligase human polycomb protein 2 (hPc2).

See all (31) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

What's a GeneRIF?

1. Our results suggest that GSCs differentially rely on ZNF131-dependent expression of HAUS5 as well as the Augmin/HAUS complex activity to maintain the integrity of centrosome function and viability.
2. identify a novel substoichiometric interactor of the complex, transcription factor ZNF131, which recruits EMSY to a large number of active, H3K4me3 marked promoters.
3. UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131
4. these data suggest that ZNF131 inhibits estrogen signaling by acting as an ERalpha-co-repressor.
5. SUMOylation is a novel regulator of ZNF131 action in estrogen signaling and breast cancer cell proliferation.
6. Interaction between ZNF131 and ERalpha interrupts or prevents ERalpha binding to the estrogen response element. ZNF131 also suppresses the expression of TFF1.
7. The mechanism of Znf131 nuclear localization, is reported. .. BR-1 and BR-2 are functional NLSs for Znf131 and as such are designated NLS-1 and NLS-2. Finally, wild type Znf131, and not a Znf131 NLS-defective mutant (NLS-1m/NLS-2m) interacted preferentially with the nuclear import receptor Importin-alpha3 in vitro.