COPS5(8q13.1), CSN5, JAB1, MOV-34, SGN5 , JAMM-alaryhmä

https://www.ncbi.nlm.nih.gov/gene/10987

Official Symbol: COPS5

Official Full Name: COP9 signalosome subunit 5

Gene type: protein coding

Also known as CSN5; JAB1; SGN5; MOV-34

Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in testis (RPKM 37.3), heart (RPKM 32.6) and 25 other tissues See more Orthologs mouse all

Preferred Names

COP9 signalosome complex subunit 5

Names

38 kDa Mov34 homolog

COP9 constitutive photomorphogenic homolog subunit 5

jun activation domain-binding protein 1

signalosome subunit 5

testis secretory sperm-binding protein Li 231m

 https://www.ncbi.nlm.nih.gov/protein/NP_006828.2

MPN+(JAMM motif)   ehhsd   (76,138, 140, 148, 151)

 JAMM motif:  138H sH pgygcwlsgi 151D

 Zn site  H, H , D

ORIGIN      
        1 maasgsgmaq ktwelannmq eaqsideiyk ydkkqqqeil aakpwtkdhh yfkyckisal
       61 allkmvmhar sggnlevmgl mlgkvdgetm iimdsfalpv egtetrvnaq aaayeymaay
      121 ienakqvgrl enaigwyHsH pgygcwlsgi Dvstqmlnqq fqepfvavvi dptrtisagk
      181 vnlgafrtyp kgykppdegp seyqtiplnk iedfgvhckq yyalevsyfk ssldrkllel
      241 lwnkywvntl sssslltnad yttgqvfdls ekleqseaql grgsfmlgle thdrksedkl
      301 akatrdsckt tieaihglms qvikdklfnq inis
//

Conserved Domains (1) summary

cd08069
Location:44 → 314

MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

Related articles in PubMed

1. CSN5/JAB1 suppresses the WNT inhibitor DKK1 in colorectal cancer cells. Jumpertz S, et al. Cell Signal, 2017 Jun. PMID 28229932
2. Oxidized LDL-induced JAB1 influences NF-κB independent inflammatory signaling in human macrophages during foam cell formation. Schwarz A, et al. J Biomed Sci, 2017 Feb 7. PMID 28173800, Free PMC Article
3. Jab1 promotes glioma cell proliferation by regulating Siah1/β-catenin pathway. Zhu Y, et al. J Neurooncol, 2017 Jan. PMID 27640199
4. JAB1 accelerates odontogenic differentiation of dental pulp stem cells. Lian M, et al. J Mol Histol, 2016 Jun. PMID 26989054
5. Suppression of CSN5 promotes the apoptosis of gastric cancer cells through regulating p53-related apoptotic pathways. Sang MM, et al. Bioorg Med Chem Lett, 2015 Aug 1. PMID 26048783

See all (249) citations in PubMed

GeneRIFs: Gene References Into Functions

1. A positive correlation was found between the expression of LASP1 and COPS5 while a negative correlation existed between 14-3-3sigma and COPS5/LASP1 in most CRC samples.
2. CSN5 directly bound survivin and decreased its ubiquitination to enhance the protein stability of survivin.
3. verexpression of COPS5, through its isopeptidase activity, leads to ubiquitination and proteasome-mediated degradation of NCoR, a key corepressor for ERalpha and tamoxifen-mediated suppression of ERalpha target genes.
4. These findings provide novel insights into molecular mechanism of let-7d and Jab1 in tumor development and progression of breast cancer, and thus let-7d/Jab1 are novel potential therapeutic targets for breast cancer patients.
5. We identified a novel Jab1-Trx axis that is a key cellular process in the pathobiologic characteristics of acute myeloid leukemia (AML-M5). Targeting the ROS/Jab1/Trx pathway could be beneficial in the treatment of AML-M5
6. These data identified CSN5 as a critical oncoprotein involved in progression of hepatocellular carcinoma (HCC) cells, which could serve as a potential therapeutic target in HCC patients.
7. The authors find that UCHL3 regulates COPS5-dependent deneddylation of Cullin1, which is an essential component of SCF(beta-TrCP) complex and associated with SCF(beta-TrCP) activities. The authors further demonstrate that Ubiquitin C-terminal hydrolase-L3 (UCHL3) upregulates the levels of SCF(beta-TrCP) substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity.
8. Collectively, our findings suggest that JAB1 activates the neuronal differentiation ability of CPNE1 through the binding of C2A domain in CPNE1 with MPN domain in JAB1.
9. data suggests that Jab1-mediated phosphorylation of p53 at Thr155 residue mediates nuclear export of p53
10. CSN5 is contributed to colorectal cancer development by actively driving aberrant WNT signaling through repression of the WNT antagonist DKK1.