2A_DUB, MYSM1, BMFS4 ( 1p32.1): uH2A- spesifinen deubikitinaasi

"MYSM1 is Involved in Maintaining Genome Stability and histone Ubiquitylation

MYSM1 is a member of the MPN+/JAMM family of DUBs. It was initially identified as a histone H2A deubiquitylating enzyme involved in regulating transcriptional programmes and epigenetic regulation of B cell differentiation [152, 153].

Furthermore, analyses of MYSM1 deficient mice uncovered a role for MYSM1 in bone marrow stem cell maintenance, control of oxidative stress and genomic stability in hematopoietic progenitors, and in the development of lymphoid and erythroid lineages [154].

Given the intricate links between epigenetic regulation of histone ubiquitylation and DNA damage responses [13], it will be interesting to further explore the roles played by MYSM1 in such processes"

https://core.ac.uk/download/pdf/82824728.pdf

Tapaan toisen kerran MYSM1- proteiinin 15.6. 2019, kun seulon geeniryhmää ”BMFS” numero numerolta, BMFS1,-2,-3,-4,-5.

BMFS4 on MYSM1.

Lisätietoa:

 https://www.cell.com/molecular-cell/fulltext/S1097-2765(07)00516-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276507005163%3Fshowall%3Dtrue

A Histone H2A Deubiquitinase Complex Coordinating Histone Acetylation 

and H1 Dissociation in Transcriptional Regulation

Ping Zhu, Wenlai Zhou  et al.  Open ArchiveDOI: https://doi.org/10.1016/j.molcel.2007.07.024

Summary

Deciphering the epigenetic “code” remains a central issue in transcriptional regulation. Here, we report the identification of a JAMM/MPN⁺ domain-containing histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that has permitted delineation of a strategy for specific regulatory pathways of gene activation. 2A-DUB regulates transcription by coordinating histone acetylation and deubiquitination, and destabilizing the association of linker histone H1 with nucleosomes.
 2A-DUB interacts with p/CAF in a coregulatory protein complex, with its deubiquitinase activity modulated by the status of acetylation of nucleosomal histones. Consistent with this mechanistic role, 2A-DUB participates in transcriptional regulation events in androgen receptor-dependent gene activation, and the levels of uH2A are dramatically decreased in prostate tumors, serving as a cancer-related mark. We suggest that H2A ubiquitination represents a widely used mechanism for many regulatory transcriptional programs and predict that various H2A ubiquitin ligases/deubiquitinases will be identified for specific cohorts of regulated transcription units.