AZGP-1 , alpha2-glykoprotein-1, Zinc binding, ZAG(7q22.1)

https://www.ncbi.nlm.nih.gov/gene/563

Preferred Names

zinc-alpha-2-glycoprotein

Names

Alpha-2-glycoprotein, zinc

Zn-alpha2-glycoprotein

testicular tissue protein Li 227

zn-alpha-2-GP

zn-alpha-2-glycoprotein

 https://www.ncbi.nlm.nih.gov/protein/NP_001176.1

ORIGIN      
        1 mvrmvpvlls lllllgpavp qenqdgrysl tyiytglskh vedvpafqal gslndlqffr
       61 ynskdrksqp mglwrqvegm edwkqdsqlq karedifmet lkdiveyynd sngshvlqgr
      121 fgceiennrs sgafwkyyyd gkdyiefnke ipawvpfdpa aqitkqkwea epvyvqraka
      181 yleeecpatl rkylkyskni ldrqdppsvv vtshqapgek kklkclaydf ypgkidvhwt
      241 ragevqepel rgdvlhngng tyqswvvvav ppqdtapysc hvqhsslaqp lvvpweas

Conserved Domains (2) summary

cd07698
Location:205 → 296

IgC_MHC_I_alpha3; Immunoglobulin (Ig) domain of major histocompatibility complex (MHC) class I alpha chain. Class I MHC proteins bind antigenic peptide fragments and present them to CD8+ T lymphocytes. Class I molecules consist of a transmembrane alpha chain and a small chain called the beta2 microglobulin. The alpha chain contains three extracellular domains, two of which fold together to form the peptide-binding cleft (alpha1 and alpha2), and one which has an Ig fold (alpha3). Peptide binding to class I molecules occurs in the endoplasmic reticulum (ER) and involves both chaperones and dedicated factors to assist in peptide loading. Class I MHC molecules are expressed on most nucleated cells.

pfam00129
Location:26 → 201

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

Related articles in PubMed

1. Serum zinc-α2-glycoprotein levels are elevated and correlated with thyroid hormone in newly diagnosed hyperthyroidism. Xiao XH, et al. BMC Endocr Disord, 2019 Jan 22. PMID 30670019, Free PMC Article
2. AZGP1 inhibits soft tissue sarcoma cells invasion and migration. Liu J, et al. BMC Cancer, 2018 Jan 22. PMID 29357838, Free PMC Article
3. A prospective multicentre phase III validation study of AZGP1 as a biomarker in localized prostate cancer. Zhang AY, et al. Ann Oncol, 2017 Aug 1. PMID 28486686
4. Zinc alpha-2 glycoprotein is overproduced in Cushing's syndrome. Escoté X, et al. Endocrinol Diabetes Nutr, 2017 Jan. PMID 28440767
5. Downregulation of AZGP1 by Ikaros and histone deacetylase (HDAC)  promotes tumor progression through the PTEN/Akt and CD44s pathways in hepatocellular carcinoma. Tian H, et al. Carcinogenesis, 2017 Feb 1. PMID 27993894

See all (125) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

1. High Zn-alpha-2-glycoprotein expression is associated with hyperthyroidism.
2. Circulating ZAG levels were significantly higher in patients with CS than in controls. ZAG levels positively correlated to 24-h urinary free cortisol, body mass index, non-esterified fatty acids, glucose, LDL-C, and type 2 diabetes mellitus, and were inversely related to total adiponectin levels.(p=0.035). In multivariate analysis ZAG levels only correlated with body mass index (p=0.012), type 2 diabetes mellitus.
3. Our study reveals that reduced AZGP1 expression correlates with in vitro cellular migration and invasion. In vivo, it is associated with higher metastatic risk and shorter survival in patients with soft tissue sarcomas
4. results indicate that changes in the circulating level of S100A1 protein occur in metabolic syndrome patients; the strong correlation between serum zinc-alpha2-glycoprotein and S100A1 might suggest that production or release of these two proteins could be related mechanistically
5. Study reports expression of Zinc-alpha2-glycoprotein (ZAG) in neurons. The level of ZAG was lower in temporal lobe epilepsy patients and time-dependently decreased in PTZ-treated rats. In addition, ZAG was shown to interact with p-ERK and TGF-beta. ZAG was found to be synthesized in neurons, and both the AZGP1 mRNA and ZAG protein levels were decreased in epilepsy patients and rat models.
6. Our study provides prospective phase III validation that absent/low AZGP1 expression provides independent prognostic value in PC
7. This study demonstrated that differential expression of zinc-alpha-2-glycoprotein (AZGP1) was detected in the serums of Alzheimer's Disease patients compared with healthy controls
8. ZAG has the potential to alleviate hepatosteatosis, making it a promising therapeutic target for fatty liver.
9. we found that AZGP1 inhibited cell migration and invasion through the regulation of the PTEN/Akt and CD44s pathways. Collectively, our findings revealed the molecular mechanism of AZGP1 expression in HCC, providing new insights into the mechanisms underlying tumor progression.
10. Absent or weak expression of AZGP1 protein was associated with worse recurrence free survival (RFS), disease specific survival, and overall survival after radical prostatectomy for prostate cancer.

Submit: New GeneRIF Correction See all GeneRIFs (69)
Krooninen munuaisvika ja ZAG;
  https://www.sciencedirect.com/science/article/pii/S0085253815558547
ZAG ylössäätynyt 573%, proteiinin ja energian menetystä.