Semaforiini-3A ,SEMA3A (7q21.1)

(1) SEMA 3A (7q21.11) Semaphorin 3A

Muita nimiä: HH16, SemD, COLL1, SEMA1, SEMAD, SEMAL, coll-1, Hsema-1, SEMAIII, Hsema-III. Proteiini on vitaali normaalin neuronaalisen rakennemallin kehkeytymiselle. Proteiinin liiallista ilmenemää esiintyy skitsofreniassa ja eri tuumorisolulinjoissa. Proteiinin poikkeava vapautuminen liittyy Alzheimerin taudin etenemiseen.

https://www.ncbi.nlm.nih.gov/gene/10371

Also known as HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III

Summary. This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]

Expression: Broad expression in placenta (RPKM 2.5), gall bladder (RPKM 2.0) and 19 other tissues See more Orthologs mouse all

Preferred Names

semaphorin-3A

Names

collapsin 1

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

semaphorin D

semaphorin III

semaphorin L

Semaphorin-3A precursor

 https://www.ncbi.nlm.nih.gov/protein/NP_006071.1

1  (residues 1 to 771)
  AUTHORS   Valiulyte I, Preitakaite V, Tamasauskas A and Kazlauskas A.
  TITLE     Importance of the putative furin recognition site 742RNRR745 for
            antiangiogenic Sema3C activity in vitro
  JOURNAL   Braz. J. Med. Biol. Res. 51 (11), e7786 (2018)

8tämän edeltäjäpeptidin Sema3A:n  vastaava RNRR on asemassa757RNRR760.  

(2)   the newly identified miR-362/Sema3A axis elucidate the molecular mechanism of NSCLC invasion and migration and could lead to a potential therapeutic target in NSCLC treatment.

  7  (residues 1 to 771)
  AUTHORS   Puschel AW, Adams RH and Betz H.
  TITLE     Murine semaphorin D/collapsin is a member of a diverse gene family
            and creates domains inhibitory for axonal extension
  JOURNAL   Neuron 14 (5), 941-948 (1995)

 

Conserved Domains (3) summary

cd05871
Location:580 → 670

Ig_Semaphorin_classIII; Immunoglobulin (Ig)-like domain of class III semaphorin

cd11249
Location:26 → 518

Sema_3A; The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A)

smart00423
Location:516 → 552

PSI; domain found in Plexins, Semaphorins and Integrins

Related arfticles.

1. Importance of the putative furin recognition site 742RNRR745 for antiangiogenic Sema3C activity in vitro. Valiulyte I, et al. Braz J Med Biol Res, 2018 Oct 8. PMID 30304095, Free PMC Article
2. Overexpression of semaphorin 3A in patients with urothelial cancer. Vadasz Z, et al. Urol Oncol, 2018 Apr. PMID 29288007
3. Anti-SEMA3A Antibody: A Novel Therapeutic Agent to Suppress Glioblastoma Tumor Growth. Lee J, et al. Cancer Res Treat, 2018 Jul. PMID 29129044, Free PMC Article
4. Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression. Zhou H, et al. JAMA Psychiatry, 2017 Dec 1. PMID 29071344, Free PMC Article
5. Semaphorin 3A: Is a key player in the pathogenesis of asthma. Cozacov R, et al. Clin Immunol, 2017 Nov. PMID 28502680 
6. https://www.ncbi.nlm.nih.gov/pubmed/18443354  HIV-1 also upregulated VEGFR2 and its co-receptor neuropilin-1 and suppressed the expression of semaphorin 3a in the podocyte

GeneRIFs: Gene References Into Functions

1. Chd7 is enriched at the Sema3a promoter in neural crest cells, and loss of function of Chd7 inhibits Sema3a expression in CHARGE syndrome.
2. Semaphorin 3A is overexpressed in urothelial cancer patients, as evidenced both in its presence in urine and in bladder tissue.
3. the inhibitory effect of Sema3C on microcapillary formation by human umbilical vein endothelial cells could be abrogated upon mutation at the Sema3C basic domain within putative furin cleavage site 742RNRR745, indicating that this site was essential for the Sema3 biological activity.
4. Results provide evidence that SEMA3A is highly expressed in glioblastoma (GBM) compared to non-neoplastic brain tissues and SEMA3A signaling axis promotes GBM growth and invasion.
5. these findings shows that miR-362 promotes lung cancer metastasis through downregulation of Sema3A
6. These findings indicate a regulatory mechanism and a proapoptotic function of aberrant Sema3A signaling in Osteoarthritis (OA) chondrocytes, and suggest that targeting Sema3A signaling might interfere OA pathogenesis.
7. increased concentrations of urinary SEMA-3A and urinary Netrin-1 are found in urine from children with severe hydronephrosis and that their concentrations are related to the degree of obstruction.
8. Advanced peri-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant.
9. clinical samples from apical periodontitis patients were obtained to analyse the expression of Sema3A/Nrp1. These results indicated that the bone destruction level expanded from days 7 to 35
10. study demonstrates that Sema3E/plexinD1 inhibits proliferation and migration of vascular smooth muscle cells via inactivation of Rap1-AKT signalling pathways

Netistä löytyy kuva Axon quiding cues. Aksonin kasvusuuntaa ohjaavien tekijöiden joukossa on Sema 3A kuvattu.

 https://www.researchgate.net/profile/Ewoud_Schmidt/publication/26289304/figure/fig5/AS:335944789053444@1457106887790/Effects-of-axon-guidance-proteins-in-ALS-Sema3A-overexpression-in-Terminal-Schwann-Cells.png