Plexin-B2, PLXNB2 (22q13.33)

https://www.ncbi.nlm.nih.gov/gene/23654

Also known as

MM1; PLEXB2; Nbla00445; dJ402G11.3

Summary

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]

Expression

Ubiquitous expression in kidney (RPKM 34.6), spleen (RPKM 29.9) and 25 other tissues See 

Preferred Names

plexin-B2

Plexin-B2 precursor:  https://www.ncbi.nlm.nih.gov/protein/NP_036533.2

OBS. Many  glycosylation sites in the structure.

 http://atlasgeneticsoncology.org/Genes/GC_PLXNB2.html

 

Conserved Domains (6) summary

cd11276
Location:27 → 467

Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2

cd01179
Location:895 → 981

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:803 → 894

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:469 → 517

PSI; Plexin repeat

pfam01833
Location:983 → 1091

TIG; IPT/TIG domain

pfam08337
Location:1271 → 1805

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

Related articles in PubMed

1. Plexin-B2 promotes invasive growth of malignant glioma. Le AP, et al. Oncotarget, 2015 Mar 30. PMID 25762646, Free PMC Article
2. Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors. Shinoura N, et al. Cancer Lett, 1995 Mar 2. PMID 7889532
3. MiR-126-3p inhibits ovarian cancer proliferation and invasion via targeting PLXNB2. Xiang G, et al. Reprod Biol, 2018 Sep. PMID 30054097
4. Rnd3-induced cell rounding requires interaction with Plexin-B2. McColl B, et al. J Cell Sci, 2016 Nov 1. PMID 27656111, Free PMC Article
5. Functional regulation of semaphorin receptors by proprotein convertases. Artigiani S, et al. J Biol Chem, 2003 Mar 21. PMID 12533544

See all (44) citations in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Knocking down of PLXNB2 with PLXNB2 siRNA results in repressed ovarian cancer cell proliferation and invasion, and decreased phosphorylation of AKT and ERK1/2
2. Study shows that plexin-B2 (PLXNB2) is the functional receptor for ANG in endothelial, cancer, neuronal, and normal hematopoietic and leukemic stem and progenitor cells.
3. Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins shows lack of binding specificity.
4. plexin-B2 is a downstream target for Rnd3, which contributes to its cellular function.
5. Results show that decreased expression of Sema4D, plexin-B1 and -B2 was associated with local recurrence and poor prognosis of breast neoplasm.
6. Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling.
7. Plexin-B2 promotes glioma invasion and vascularization
8. Blocking of CD100, plexin B1 and/or B2 in adhesion experiments have shown that both CD100 and plexins act as adhesion molecules involved in monocyte-endothelial cell binding.
9. In endometrial luminal epithelium, cadherin 6, desmoglein 2 and plexin b2 were surprisingly found in the apical as well as the lateral membrane domain; their knock-down compromised epithelial integrity.
10. High PLEXIN B2 expression is associated with high-grade gliomas.