Plexin -C1, PLXNC1 (12q22)

https://www.ncbi.nlm.nih.gov/gene/10154

Also known as

CD232; VESPR; PLXN-C1

Summary:  This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]

Expression: Broad expression in appendix (RPKM 8.1), testis (RPKM 6.6) and 23 other tissues See more

Preferred Names

plexin-C1

Names

plexin (semaphorin receptor)

receptor for viral semaphorin protein

receptor for virally-encoded semaphorin

virus-encoded semaphorin protein receptor

 Plexin C1 precursor 

https://www.ncbi.nlm.nih.gov/protein/NP_005752.1

N-glycosylations (15 sites), One Phosphoserin site, Rap interface

 

Conserved Domains (6) summary

cd11246
Location:44 → 453

Sema_plexin_C1; The Sema domain, a protein interacting module, of Plexin C1

smart00423
Location:591 → 635

PSI; domain found in Plexins, Semaphorins and Integrins

smart00429
Location:753 → 841

IPT; ig-like, plexins, transcription factors

pfam01437
Location:454 → 507

PSI; Plexin repeat

pfam01833
Location:664 → 750

TIG; IPT/TIG domain

pfam08337
Location:1012 → 1535

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

 

Related articles in PubMed

1. Mechanical tension alters semaphorin expression in the periodontium. Spencer AY, et al. J Periodontol, 2009 Oct. PMID 19792857
2. Molecular profiling of the "plexinome" in melanoma and pancreatic cancer. Balakrishnan A, et al. Hum Mutat, 2009 Aug. PMID 19462467, Free PMC Article
3. Identification of genes with abnormal expression changes in acute myeloid leukemia. Stirewalt DL, et al. Genes Chromosomes Cancer, 2008 Jan. PMID 17910043
4. Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectively. Chabbert-de Ponnat I, et al. Int Immunol, 2005 Apr. PMID 15746246
5. A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR. Comeau MR, et al. Immunity, 1998 Apr. PMID 9586637

See all (23) citations in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Results indicate that long non-coding RNA (lncRNA) CASC2 can promote PLXNC1 expression by sponging miR-181a, thereby inhibiting the proliferation and invasion of melanoma cells.
2. Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis
3. loss of Plexin C1 in melanoma may promote early steps in melanoma progression through suppression of migration and proliferation
4. Study reports the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1; both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers.
5. significant loss of Plexin C1 in metastatic melanoma compared with primary melanoma, suggesting the possibility that the Plexin C1 receptor is a tumor suppressor protein for melanoma
6. Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression.
7. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
8. GTP-bound form of Rab7 promotes melanogenesis through the regulation of gp100 maturation in melanoma cells.

Summaries for PLXNC1 Gene

Entrez Gene Summary for PLXNC1 Gene

• This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
  

GeneCards Summary for PLXNC1 Gene

PLXNC1 (Plexin C1) is a Protein Coding gene. Diseases associated with PLXNC1 include Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease. Among its related pathways are Semaphorin interactions and Axon guidance. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is PLXND1.

UniProtKB/Swiss-Prot for PLXNC1 Gene

• PLXC1_HUMAN,O60486

• Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).
  

Additional gene information for PLXNC1 Gene

• HGNC(9106)
• Entrez Gene(10154)
• Ensembl(ENSG00000136040)
• OMIM(604259)
• UniProtKB(O60486)
•