Plexin-A3 , PLXNA3 (Xq28)

https://www.ncbi.nlm.nih.gov/gene/55558
 Muita nimiä
6.3
PLXN3,PLXN4
XAP-6,
HSSEXGENE

Also known as

6.3; PLXN3; PLXN4; XAP-6; HSSEXGENE

Summary  This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]

Expression Ubiquitous expression in skin (RPKM 7.2), ovary (RPKM 7.2) and 25 other tissues See more

Preferred Names

plexin-A3

Names

Sex chromosome X transmembrane protein of HGF receptor family 3

plexin-4

semaphorin receptor SEX

Related articles in PubMed

1. PLXNA3 Variant rs5945430 is Associated with Severe Clinical Course in Male Multiple Sclerosis Patients. Qureshi M, et al. Neuromolecular Med, 2017 Sep. PMID 28536997
2. Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner. Fiedler SE, et al. FEBS Lett, 2010 Mar 5. PMID 20138877
3. PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure. Belyk M, et al. J Hum Genet, 2015 Mar. PMID 25518740, Free PMC Article
4. Semaphorin-plexin signalling genes associated with human breast tumourigenesis. Gabrovska PN, et al. Gene, 2011 Dec 10. PMID 21925246
5. Identification of plexin family molecules in mice. Kameyama T, et al. Biochem Biophys Res Commun, 1996 Sep 13. PMID 8806646
6.  

   REFERENCE   8  (residues 1 to 1871)
     AUTHORS   Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione
               S, Tamanini F, Neel BG, Toniolo D and Comoglio PM.
     TITLE     A family of transmembrane proteins with homology to the
               MET-hepatocyte growth factor receptor
     JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (2), 674-678 (1996)

GeneRIFs:

1. Exome analysis of Kuwaiti multiple sclerosis patients revealed a missense variant (rs5945430) in Plexin A3 (PLXNA3) gene (Xq28) associated with male-specific MS severity and disability.
2. Data indicate that plexin A1-4 (PLXNA1-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.
3. in vitro analysis on PLXNA3 also suggest that this gene may have some form of growth suppressive role in breast cancer, in addition to a similar role for the gene previously reported in ovarian cancer.
4. Data show that the expression of Sema3A receptors (neuropilin-1 (NRP-1), NRP-2, plexin A1, plexin A2, and plexin A3) significantly increased during M-CSF-mediated differentiation of monocytes into macrophages.
5.  https://ai2-s2-public.s3.amazonaws.com/figures/2017-08-08/58a00efcb2930ad1a37653ff0fc718f2d0dd4c5b/9-Figure8-1.pngPreferential association model for plexins and neuropilins in class 3 semaphorin signaling.(Figure)  

 

Precursor Plexin-3A. 1871 aminoacids :

 https://www.ncbi.nlm.nih.gov/protein/NP_059984.3

 

Conserved Domains (8) summary

https://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi?seqinput=NP_059984.3

cd11273
Location:21 → 489

Sema_plexin_A3; The Sema domain, a protein interacting module, of Plexin A3

smart00423
Location:788 → 831

PSI; domain found in Plexins, Semaphorins and Integrins

cd00603
Location:1125 → 1208

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.

cd01179
Location:935 → 1021

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:840 → 934

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1023 → 1123

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:490 → 530

PSI; Plexin repeat

pfam08337
Location:1294 → 1841

Plexin_cytopl;

Plexin cytoplasmic RasGAP domain

This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.