Plexiini-B3, PLXNB3 (Xq28)

https://www.ncbi.nlm.nih.gov/gene/5365
 https://www.uniprot.org/uniprot/Q9ULL4

Also known as

PLEXR; PLXN6; PLEXB3

Summary

The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Expression

Broad expression in brain (RPKM 10.9), salivary gland (RPKM 4.4) and 16 other tissues See more

Preferred Names

plexin-B3

Names

plexin 6

 https://www.ncbi.nlm.nih.gov/protein/NP_001156729.1

( Interesting sequence of aminoacids.  leucine-rich  motif series

Related articles in PubMed

1. Plexin B3 is genetically associated with verbal performance and white matter volume in human brain. Rujescu D, et al. Mol Psychiatry, 2007 Feb. PMID 17033634
2. Identification of semaphorin 5A interacting protein by applying apriori knowledge and peptide complementarity related to protein evolution and structure. Sadanandam A, et al. Genomics Proteomics Bioinformatics, 2008 Dec. PMID 19329067, Free PMC Article
3. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. Perrot V, et al. J Biol Chem, 2002 Nov 8. PMID 12183458
4. The genomic organization of a human creatine transporter (CRTR) gene located in Xq28. Sandoval N, et al. Genomics, 1996 Jul 15. PMID 8661155
5. Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton. Li X, et al. Oncogene, 2012 Feb 2. PMID 2170605

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Data show that Semaphorin 5A (Sema5A) and plexin-B3 inhibit glioma cell invasion through Rac1 inactivation.
2. Data represent a novel signaling of semaphorin 5A and plexin B3 in the control of cell motility by indirect inactivation of Rac1 through RhoGDIalpha.
3. A virtual expression database search and RT-PCR analysis showed co-expression of SEMA5A and Plexin B3, and the interaction of SEMA5A with Plexin B3 was confirmed by co-immunoprecipitation studies.
4. Plexin-B3 is a functional receptor for semaphorin 5A
5. plexin B3 may influence cognitive performance, and the development of white matter in vivo in a way similar to its known stimulating effect on neurite outgrowth in vitro
6. Data suggest an involvement of homophilic interaction of B3 in semaphorin-independent signaling mechanisms positively influencing neuronal morphogenesis or function.  Abstract BACKGROUND:
   Plexins, known to date as receptors of semaphorins, are implicated in semaphorin-mediated axon repulsion and growth cone collapse. However, subtype-specific functions of the majority of the nine members of the mammalian plexin family are largely unknown. In order to investigate functional properties of B-plexins, we analyzed the expression of human and murine plexin B3 and expressed full-length human plexins B2 (B2) and B3 (B3) in NIH-3T3 cells. RESULTS:
   Unexpectedly, B3 strongly and B2 moderately stimulate neurite outgrowth of primary murine cerebellar neurons. Both plexins mediate Ca2+/Mg2+-dependent cell aggregation due to homophilic trans-interaction, which is strong in the case of B3 and moderate for B2. Using different deletion constructs we show that the sema domain of B3 is essential for homophilic interaction. Using yeast two-hybrid analysis, we identified the neuron-specific and calmodulin-binding Ras-related GTPase Rin as an interaction partner of the intracellular part of B3, but not of B2. Rin, also known for its neurite outgrowth-inducing characteristics, co-localizes and co-immunoprecipitates with B3 in co-transfected COS-7 cells. CONCLUSION:
   Our data suggest an involvement of homophilic interaction of B3 in semaphorin-independent signaling mechanisms positively influencing neuronal morphogenesis or function. Furthermore the neuron-specific small GTPase Rin is involved in downstream signaling of plexin B3.