Tällainenkin ajatus tänään. Voiko olla herediteettiä jodiallergialle? Miten ehkäistä jodipitoisen kontrastiaineen (ICM) aiheuttamaa reaktiota?

• Tämä muistuu sillon tällöin mieleen, kun isäni sanoi olevansa jodille allerginen ja sai jodipitoisista aineista aina  kovan yskänärsytyksen. Hänen yksi  hederitäärinen tautinsa oli B12-puute, johon tarvitsi B12 injektioita, joita juuri hänen sairastumisensa aikaan oli keksitty maailmassa, ettei tarvinnut syödä raakaa maksaa. 

• Mikä voisi ehkäistä  jodipitoisten  kontrastiaineiden aiheuttamaa allergiaa/anafylaksiaa?  tästä löydän pari lääkeainetta , joista  voisi olla hyötyä: prednison ja terbutaliini ( Bricanyl). Erilaiset antihistamiinit eivät ole olleet  avuksi.  Reaktiossa on tyypillistä keuhko-ödemapiirteet varsinkin pulmonaarisesa hypertensiossa.

• Löytyy jotain hereditääristä tekijää jodiherkkyyksissä.  Entä hereditäärisen  B12 puuteen jonkin syysn genetiikan assosiaatio tähän?

. 2020 May;55(5):304-309.

doi: 10.1097/RLI.0000000000000644.

HLA-DRB1*15: 02 Is Associated With Iodinated Contrast Media-Related Anaphylaxis

Soo Jie Chung, Dong Yoon Kang, Whal Lee  ¹ , Seung Bok Lee  ² , Sujeong Kim  ³ , Seung-Eun Lee  ⁴ , Da Woon Sim  ⁵ , Min-Gyu Kang  ⁶ , Kyung Hee Park  ⁷ , Jae-Woo Jung  ⁸ , James Yun, Hye-Ryun Kang

Affiliations

• PMID: 31985601
• DOI: 10.1097/RLI.0000000000000644

Abstract

Background: The incidence of severe reaction induced by iodinated contrast media (ICM) has increased over the years with an increasing use of imaging modalities. Although ICM anaphylaxis is rare, it can be life-threatening, but currently, there is no biomarker that can identify individuals at risk of ICM anaphylaxis.

Objective: The aim of this study is to investigate the genetic susceptibility of ICM anaphylaxis.

Methods: Patients who had ICM anaphylaxis were enrolled in the study, and their blood samples were collected for genotyping of human leukocyte antigen (HLA)-A, -B, -C, and -DR. The results were compared with those of healthy Korean general population. MRGPRX2 gene in ICM anaphylaxis group was also sequenced and compared with the Korean standard database of genetic polymorphism.

Results: The frequencies of 3 HLA alleles (B*52:01, C*12:02, and DRB1*15:02) were significantly higher in 47 patients with ICM anaphylaxis. In particular, HLA-DRB1*15:02 was 5 times more frequent in the ICM anaphylaxis group than the Korean general population (34.0% vs 6.6%; odds ratio, 7.306; 95% confidence interval, 3.622-14.740), and this difference was most pronounced in subjects with iohexol-induced anaphylaxis (odds ratio, 16.516; 95% CI, 5.241-52.047; P < 0.0001). Eight single nucleotide polymorphisms were identified in MRGPRX2 gene, but their frequencies were not different in those with ICM anaphylaxis compared with the general Korean population.

Conclusions: HLA-DRB1*15:02 is associated with ICM anaphylaxis in the Korean population.

https://pubmed.ncbi.nlm.nih.gov/6783164/