Histokompatibiliteetti " Master Control factor" CIITA Immuunivasteen tärkeää geenivarustetta.

 Immuunivasteelle  tärkeää  genomivarustetta: 

GeneCards: https://www.genecards.org/cgi-bin/carddisp.pl?gene=CIITA&keywords=CIITA

Aliases for CIITA Gene

• GeneCards Symbol: CIITA ²
• Class II Major Histocompatibility Complex Transactivator ^{2 3 5}
• MHC Class II Transactivator ^{2 3 4}
• MHC2TA ^{3 4 5}
• C2TA ^{2 3 5}
• NLRA ^{2 3 5}
• Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Acid Domain Containing ^{2 3}

• NLR Family, Acid Domain Containing ^{2 3}
• Class II, Major Histocompatibility Complex, Transactivator ²
• MHC Class II Transactivator Type III ³
• MHC Class II Transactivator Type I ³
• EC 2.7.11.1 ⁴
• EC 2.3.1.- ⁴
• CIITAIV ³

External Ids for CIITA Gene

. 2020 Oct 9;370(6513):241-247.

doi: 10.1126/science.abb3753. Epub 2020 Aug 27.

MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses

Anna Bruchez ^{#  1} , Ky Sha ^{#  1} , Joshua Johnson  ² , Li Chen  ³ , Caroline Stefani  ¹ , Hannah McConnell  ¹ , Lea Gaucherand  ¹ , Rachel Prins  ¹ , Kenneth A Matreyek  ⁴ , Adam J Hume  ^{5   6} , Elke Mühlberger  ^{5   6} , Emmett V Schmidt  ⁷ , Gene G Olinger  ^{2   5   6   8} , Lynda M Stuart  ^{1   9} , Adam Lacy-Hulbert  ^{10   11}

Affiliations

• PMID: 32855215
• PMCID: PMC7665841
• DOI: 10.1126/science.abb3753

Free PMC article

UniProtKB/Swiss-Prot Summary for CIITA Gene

• Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2. Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215).

  • C2TA_HUMAN,P33076