Leta i den här bloggen

torsdag 11 juni 2020

ZNF800 - ZNF823 (C2H2 sinkkisormimotiivi)

Nucleic Acids Res .2009 Jan;37(Database issue):D267-73.
doi: 10.1093/nar/gkn782. Epub 2008 Oct 30. SysZNF: The C2H2 Zinc Finger Gene DatabaseGuohui Ding  1 , Peter Lorenz, DOI: 10.1093/nar/gkn78 Free PMC article Abstract


C2H2 zinc finger (C2H2-ZNF) genes are one of the largest and most complex gene super-families in metazoan genomes, with hundreds of members in the human and mouse genome. The ongoing investigation of this huge gene family requires computational support to catalog genotype phenotype comparisons of C2H2-ZNF genes between related species and finally to extend the worldwide knowledge on the evolution of C2H2-ZNF genes in general. Here, we systematically collected all the C2H2-ZNF genes in the human and mouse genome and constructed a database named SysZNF to deposit available datasets related to these genes. In the database, each C2H2-ZNF gene entry consists of physical location, gene model (including different transcript forms), Affymetrix gene expression probes, protein domain structures, homologs (and synteny between human and mouse), PubMed references as well as links to relevant public databases. The clustered organization of the C2H2-ZNF genes is highlighted. The database can be searched using text strings or sequence information. The data are also available for batch download from the web site. Moreover, the graphical gene model/protein view system, sequence retrieval system and some other tools embedded in SysZNF facilitate the research on the C2H2 type ZNF genes under an integrative view. The database can be accessed from the URL http://epgd.biosino.org/SysZNF.

Teen itse   tämän  C2H2-ZNF geenien hakua. Aloitan  11.6. 2020: Gene Cards  avulla ja keotan löytää ensin yläpään. tosin en onnsitu heti hahmoittamaan ylintä jhoten aloitan geenistä 823  ja katson alaspäin  geeniin ZNF800 asti  tässä  artikkelissa.  Löytyy toki  korkeampia numeroitakin. Esim ZNF888. Ajan mitaan katson näitä myös.


ZNF823 (19p13.2),

 ZFP36 for a zinc finger protein
HSZPF-36. May be transcription factor.
Disease: Corneal dystrophy, Band-Shape.
Pathway: herpes Simplex Virus 1 infection.

ZNF822 (16q23.2),  ATM interactor, ATMIN

ATM Interactor 2 3 4 5
ATM/ATR-Substrate Chk2-Interacting Zn++-Finger Protein 2 3
ATM/ATR-Substrate CHK2-Interacting Zinc Finger Protein 3 4
Zinc Finger Protein 822 3 4
ATM INteracting Protein 2 3
ZNF822 3 4
ASCIZ 3 4
ATM/ATR-Substrate CHEK2-Interacting Zinc Finger Protein 3
KIAA0431 4
ATMIN (ATM Interactor) is a Protein Coding gene. Among its related pathways are ATM Signaling Network in Development and Disease. Gene Ontology (GO) annotations related to this gene include transcription regulatory region DNA binding. An important paralog of this gene is RIOK2. UniProtKB/Swiss-Prot Summary for ATMIN Gene: Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. ATMIN_HUMAN,O43313 Protein attributes for ATMIN Gene. Size: 823 amino acids Molecular mass: 88348 Da Quaternary structure: Interacts via its C-terminus with ATM. Interacts with DYNLL1; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN.

ZNF821 (16q22.2), Zinc Finger Protein 821

The STPR domain binds to dsDNA
This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] GeneCards Summary for ZNF821 Gene
ZNF821 (Zinc Finger Protein 821) is a Protein Coding gene. Diseases associated with ZNF821 include Tyrosinemia, Type Ii. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is IKZF4. UniProtKB/Swiss-Prot Summary for ZNF821 Gene: May be involved in transcriptional regulation. ZN821_HUMAN,O75541 Protein attributes for ZNF821 Gene: Size: 412 amino acids. Molecular mass: 46794 Da. Quaternary structure: No Data Available

ZNF820 -

ZNF819 -

ZNF818P (19q13.41) pseudogene , Putative Zinc Finger protein 818.

 May be: Transcription regulator Protein attributes for ZNF818P Gene
Size: 136 amino acids Molecular mass: 15513 Da Quaternary structure: No Data Available
ZNF817 -

ZNF816, ZNF816A , (19q13.41),      https://www.genecards.org/cgi-bin/carddisp.pl?gene=ZNF816&keywords=ZNF816 Pathway: HSV-1 infection. Paralog: ZNF813. 615 aa.

ZNF815P , (7p22.1) , Putative protein ZNF815.

130 a.a. 
 Aliases for ZNF815P Gene,
Zinc Finger Protein 815, Pseudogene 2 3 5
Putative Protein ZNF815 3 4
ZNF815 3 4
Zinc Finger Protein Pseudogene 3
Zinc Finger Protein 815 2
Previous HGNC Symbols for ZNF815P Gene
ZNF815

ZNF814, (19q13.439, Zinc Finger protein 814 

855 a.a.

ZNF813, (19q13.43),  Zinc finger protein 813.

Pathway HSV-1 infection. May be involved I transcriptional regulation.
617 a.a. Paralog: ZNF888.

ZNF812P (19p13.2), Zinc finger protein 812, Pseudogene.


ZNF811 -
ZNF810 -
ZNF809 -

ZNF808 

ZNF807 (19q13.11) , Zinc finger protein 807, Pseudogene, ZNF181P1

ZNF806
ZNF805 (2q21.2)
CTC-44424.8. Nucleic acid binidng. HSV-1 infection, pathways. 627 aa.

ZNF804A ,(2q32.1), C2orf10. Polymorfiaa. ‘’
Associoituu neuropsyk. Tauteihin ja heroiinin addiktioon. Paralog GPATCH8. 1208 aa.

ZNF803 , WIZ, (19p13.12), Protein WIZ, 1651 a.a.
  • WIZ Zinc Finger 2 3 5
  • Widely-Interspaced Zinc Finger-Containing Protein 3 4
  • Widely Interspaced Zinc Finger Motifs 2 3
  • Zinc Finger Protein 803 3 4
  • Protein Wiz 3 4
  • ZNF803 3 4
WIZ (WIZ Zinc Finger) is a Protein Coding gene. Diseases associated with WIZ include Exstrophy Of Bladder and Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex. Gene Ontology (GO) annotations related to this gene include SET domain binding. An important paralog of this gene is ZNF646 UniProtKB/Swiss-Prot Summary for WIZ Gene May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). WIZ_HUMAN,O95785
Quaternary structure: Interacts with EHMT1, EHMT2, CTBP1 and CTBP2 (By similarity). Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2.
SequenceCaution: Sequence=BAB55234.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Post-translational modifications for WIZ Gene Ubiquitination at Lys1597 NX_O95785 (NX_O95785-1)


ZNF802, Aliases for JAZF1 Gene
https://www.genecards.org/cgi-bin/carddisp.pl?gene=JAZF1&keywords=ZNF802
  • JAZF Zinc Finger 1 2 3 5
  • Juxtaposed With Another Zinc Finger Protein 1 3 4
  • TAK1-Interacting Protein 27 3 4
  • Zinc Finger Protein 802 3 4
  • ZNF802 3 4
  • TIP27 3 4
  • Juxtaposed With Another Zinc Finger Gene 1
This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008] GeneCards Summary for JAZF1 Gene JAZF1 (JAZF Zinc Finger 1) is a Protein Coding gene. Diseases associated with JAZF1 include Endometrial Stromal Sarcoma and Endometrial Stromal Nodule. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity. UniProtKB/Swiss-Prot Summary for JAZF1 Gene Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity). JAZF1_HUMAN,Q86VZ6 Protein attributes for JAZF1 Gene Size: 243 amino acids Molecular mass: 27079 Da Quaternary structure: Interacts with NR2C2 (via ligand-binding region). Miscellaneous: Under hypoxic conditions, the precursor SUZ12 RNA undergoes regulated trans-splicing with the JAZF1 RNA, resulting in a chimeric isoform which may be protective against apoptosis. The chimeric transcript is characterized by JAZF1 exons 1-3 joined to SUZ12 exon 2-16. The chimeric transcript is expressed primarily in the endometrium from late secretory and early proliferative phases of the menstrual cycle, but not in normal myometrium at any phase of the cycle. Its expression is slightly induced by low levels of progesterone, but suppressed by both estrogen and high levels of progesterone (PubMed:18772439). [Isoform 2]: Incomplete sequence.

ZNF801, (16p11.2) . MAZ, MYC associated Zinc Finger protein
Aliases for MAZ Gene
  • MYC Associated Zinc Finger Protein 2 3 5
  • Purine-Binding Transcription Factor 2 3 4
  • Myc-Associated Zinc Finger Protein 3 4
  • Transcription Factor Zif87 3 4
  • Zinc Finger Protein 801 3 4
  • ZNF801 3 4
  • Pur-1 3 4
  • SAF-1 3 4
  • MAZI 3 4
  • ZF87 3 4
  • MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) 2
  • Serum Amyloid A Activating Factor 1 3
  • Serum Amyloid A Activating Factor 2 3
  • Zinc-Finger Protein, 87 Kilodaltons 3
  • Serum Amyloid A-Activating Factor-1 4
  • SAF-2 3
  • SAF-3 3
  • Zif87 3
  • PUR1 3
MAZ (MYC Associated Zinc Finger Protein) is a Protein Coding gene. Diseases associated with MAZ include Amyloidosis and Alzheimer Disease. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is PATZ1. UniProtKB/Swiss-Prot Summary for MAZ Gene May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins. MAZ_HUMAN,P56270 . Quaternary structure: Interacts with BPTF. Miscellaneous: [Isoform 2]: May act as a dominant negative of isoform 1. Reduced expression during inflammatory conditions. [Isoform 3]: Very low expression in normal tissues, but high expression during inflammation. The transactivation potential of SAF-3 is much greater than that of the predominantly expressed form 1.



ZNF800, (7q31.33)
https://www.genecards.org/cgi-bin/carddisp.pl?gene=ZNF800&keywords=ZNF800
664 a.a. , May be involved in trnscriptional regulation.










Upplagd av kl.
Etiketter:

Inga kommentarer:

Skicka en kommentar

Prenumerera på: Kommentarer till inlägget (Atom)