HYOU1 geeni on Sars2 viruksen on ORF8 proteiinin interaktioproteiineja (EROMI jäsenenä)

https://www.genecards.org/cgi-bin/carddisp.pl?gene=HYOU1&keywords=HYOU1Aliases for HYOU1 Gene

• Hypoxia Up-Regulated 1 ^{2 3 5}
• 170 KDa Glucose-Regulated Protein ^{3 4}
• 150 KDa Oxygen-Regulated Protein ^{3 4}
• Hypoxia Up-Regulated Protein 1 ^{3 4}
• GRP-170 ^{3 4}
• ORP-150 ^{3 4}
• ORP150 ^{3 4}

• Epididymis Secretory Sperm Binding Protein ³
• Oxygen Regulated Protein (150kD) ³
• Glucose-Regulated Protein 170 ²
• Grp170 ³
• HSP12A ³
• GRP170 ⁴
• IMD59 ³

HYOU1 Gene:  The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be upregulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol.

GeneCards Summary for HYOU1 Gene

HYOU1 (Hypoxia Up-Regulated 1) is a Protein Coding gene. Diseases associated with HYOU1 include Immunodeficiency 59 And Hypoglycemia and Hypoxia. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Unfolded Protein Response (UPR). Gene Ontology (GO) annotations related to this gene include chaperone binding. An important paralog of this gene is HSPA4.

UniProtKB/Swiss-Prot Summary for HYOU1 Gene

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding HYOU1_HUMAN,Q9Y4L1 Protein attributes for HYOU1 Gene: Size: 999 amino acids.  Molecular mass: 111 Quaternary structure: Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

 https://www.researchgate.net/figure/Oxygen-deprivation-results-in-distinct-transcriptional-changes-of-the-ERome-A_fig1_258700637