ZNF384 tumamatriksin transkriptiotekijä NP/NMP4

https://www.ncbi.nlm.nih.gov/gene/171017

Official Symbol

ZNF384p

Official Full Name

zinc finger protein 384

Also known as

NP; CIZ; NMP4; CAGH1; ERDA2; TNRC1; CAGH1A

Summary

This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]

Expression

Ubiquitous expression in bone marrow (RPKM 12.2), testis (RPKM 12.0) and 25 other tissues See more

Preferred Names

zinc finger protein 384

Names

CAG repeat protein 1

Cas-interacting zinc finger protein

expanded repeat domain, CAG/CTG 2

nuclear matrix transcription factor 4

trinucleotide repeat-containing gene 1 protein