ZGRF, GRF-tyyppiset sinkkisormiproteiinit ovat seitsemän ZGRF.geenin koodaamia

ZGRF1, (4q25). Zinc  Finger GRF-type containing.  Nucleic acid binding domain:  in the middle there are  three   conserved aminoacids G, R and F as a motif in this group of Zinc finger proteins.
 https://www.genecards.org/cgi-bin/carddisp.pl?gene=ZGRF1&keywords=ZGRF1


ZGFR2,(Xp11.2),  APEX2 , DNA-(apurinic or apyrimidinic site) lyase 2 , AP endonuclease. https://www.genecards.org/cgi-bin/carddisp.pl?gene=APEX2&keywords=ZGRF2
 Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
APEX2_HUMAN,Q9UBZ4
ZGFR3, (4q34.3),  Endonuclease 8 like 3.  NEIL3.
 NEIL3i like DNA glycosylase 3 (initiating ( The  first step in BER Base Excision  Repair) ( Contains even  Zf-RanBP2-like domain as  ZRANB )
 https://www.genecards.org/cgi-bin/carddisp.pl?gene=NEIL3&keywords=ZGRF3
 DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair. NEIL3_HUMAN,Q8TAT5

ZGFR4, (4p15.2), Recommended name: rRNA N6-adenosine-methyltransferase ZCCHC4
ZCCHC4, Even  DHHC -domain containig  Znf protein (conserved domain  409- 438 Zf- DHHC palmityltransferase)
  https://www.genecards.org/cgi-bin/carddisp.pl?gene=ZCCHC4&keywords=ZGRF4

ZGFR5, (16p12.3), ERI2,   Recommended name: ERI1 exoribonuclease 2
https://www.genecards.org/cgi-bin/carddisp.pl?gene=ERI2&keywords=ZGRF5

ZGFR6, (1p13.1), TTF2,  Recommended name:Transcription termination factor 2
 https://www.genecards.org/cgi-bin/carddisp.pl?gene=TTF2&keywords=ZGRF6   This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]  Aldosteronisynthesis  pathways.

ZGFR7, (17p11.2), TOP3A, DNA topoisomerase  III alpha. (Contains  ssDNA binding  Zn finger and  Zn ribbon)   Recommended name:  DNA topoisomerase 3-alpha
https://www.genecards.org/cgi-bin/carddisp.pl?gene=TOP3A&keywords=ZGRF7