KLHDC8B (3p21.31), CHL, on tärkeä genomin vakaudelle ja suojaa mitoosivirheiltä ja ,sentrosomiamplifikaatiolta

https://www.ncbi.nlm.nih.gov/gene/200942
Tämä Kelch-superperheen jäsen  suojelee mitoottisilta virheiltä, sentrosomien  amplifikaatioilta ja kromosomaaliselta  epävakaudelta (2012). Tämän KLHDC8B:n mutaatio assosioituu Hodginin lymfoomaan ja siinä tavattaviin binukleaarisiin Reed-Stenberg-soluihin.

Entrez Gene Summary for KLHDC8B Gene

• This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010]
  

GeneCards Summary for KLHDC8B Gene

KLHDC8B (Kelch Domain Containing 8B) is a Protein Coding gene. Diseases associated with KLHDC8B include Lymphoma, Hodgkin, Classic and Hodgkin's Lymphoma, Nodular Sclerosis. An important paralog of this gene is KLHDC8A.

UniProtKB/Swiss-Prot Summary for KLHDC8B Gene

• Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010).

  • KLD8B_HUMAN,Q8IXV7