ESCRT-0, HRS (Kr.17q25.3)

HRS , HGS (Kr.17q25.3) 

(Kr.17q25.3) Hepatocyte growth factor-regulated tyrosine kinase substrate

Ubiqitous 27 tissues

Conserved Domains (6) summary

cd03569
Location:4 → 145

VHS_Hrs_Vps27p; VHS domain family, Hrs and Vps27p subfamily; composed of Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and its yeast homolog Vps27p (vacuolar protein sorting). The VHS domain, an essential part of Hrs/Vps27p, has a superhelical ...

cd15720
Location:159 → 219

FYVE_Hrs; FYVE domain found in hepatocyte growth factor (HGF)-regulated tyrosine kinase substrate (Hrs) and similar proteins

pfam07223
Location:519 → 746

DUF1421; Protein of unknown function (DUF1421)

pfam12210
Location:407 → 501

Hrs_helical; Hepatocyte growth factor-regulated tyrosine kinase substrate

cd16269
Location:531 → 542

GBP_C; coiled coil [structural motif]

cl20817
Location:486 → 560

GBP_C; Guanylate-binding protein, C-terminal domain

Peptide structures

https://www.ncbi.nlm.nih.gov/protein/NP_004703.1

Related articles in PubMed

1. A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1. Canal F, et al. BMC Cancer, 2015 Dec 29. PMID 26715116, Free PMC Article
2. An essential role of Hrs/Vps27 in endosomal cholesterol trafficking. Du X, et al. Cell Rep, 2012 Jan 26. PMID 22832105
3. Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway. Tamai K, et al. Virology, 2012 Jan 20. PMID 22138215
4. Clinical value of plasma hepatocyte growth factor measurement for the diagnosis of periampullary cancer and prognosis after pancreaticoduodenectomy. Barakat O, et al. J Surg Oncol, 2010 Dec 1. PMID 20812348
5. ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane. Truschel ST, et al. Traffic, 2009 Sep. PMID 19624486, Free PMC Article
   

See all (173) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Results demonstrate the existence of crosstalk between beta-catenin signaling and HGS in two different types of cancer (hepatoblastoma and colorectal).
2. detailed analysis of the subcellular localization and functional significance of Hrs in macropinocytosis-mediated entry of Kaposi's Sarcoma-Associated Herpesvirus
3. ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.
4. we identified an interaction between EsxH, which is secreted by the Esx-3 TSSS, and human hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs/Hrs), a component of the endosomal sorting complex required for transport (ESCRT).
5. the role for tumoral c-Met expression or sMet/HGF levels as upfront selection criterion or predictive biomarkers deserve further study in this emerging area of therapeutic focus in RCC
6. Hrs is a regulator of endosomal cholesterol trafficking.
7. Hrs tyrosine phosphorylation detected upon EGF-stimulation.
8. These results suggested that HCV secretion from host cells requires Hrs-dependent exosomal pathway in which the viral assembly is also involved.
9. Hrs inhibits HIV-1 production by inhibiting citron kinase-mediated exocytosis.
10. ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation.
    

Submit: New GeneRIF Correction See all GeneRIFs (36)