- UUTTA TIEDETTÄ GATA Domaanin sisältävistä ZNF proteiineista:
- . 2022 Feb 1:9:795680.doi: 10.3389/fcell.2021.795680. eCollection 2021.
Two Isoforms of serpent Containing Either One or Two GATA Zinc Fingers Provide Functional Diversity During Drosophila DevelopmentAffiliations PMID: 35178397PMCID: PMC8844375
- DOI: 10.3389/fcell.2021.795680
- " They play essential roles in many developmental processes by regulating cell proliferation, cell-fate specification and differentiation. In mammals, they ensure critical roles in formation of the ectodermal-derived nervous system, endodermal gastrointestinal tract and liver, as well as mesodermal-derived hematopoietic system, cardiovascular system, gonads, and kidneys (Lentjes et al., 2016; Dobrzycki et al., 2020). Their importance throughout development was further substantiated by genome, exome and transcriptome sequencing that has led to the identification of a huge number of GATA mutations in patients with different biological disorders (Fujiwara and Fujiwara, 2017; Tremblay et al., 2018). The type of disease depends on the affected GATA gene and its expression pattern. For example, GATA1, GATA2 and GATA3 proteins are expressed in hematopoietic cell lineages, and mutations affecting these factors are related to numerous hematological disorders like myelodysplastic syndromes, Emberger syndrome, ß-thalassemia and various leukemia (Crispino and Horwitz, 2017). As GATA3 is also expressed in developing and differentiated mammary glands, as well as in embryonic kidney, inner ear and parathyroid glands, its mutations are found in breast cancer (Kouros-Mehr et al., 2008) and in hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome (Esch et al., 2000). Likewise, mutations affecting the GATA4, GATA5 and GATA6 factors that are expressed during the mammalian heart development, are associated to cardiac diseases (Whitcomb et al., 2020).
- At the structural level, the GATA factors zinc finger domains have a Cys-X2-Cys-X17-Cys-X2-Cys consensus sequence followed by a conserved basic amino acid-containing region necessary for DNA binding. In vertebrates, all the six GATA factors (GATA1 to GATA6) contain two zinc finger domains, referred to as N-ZnF and C-ZnF. DNA-binding is mainly established by the C-ZnF and its adjacent basic C-terminal region (Yang and Evans, 1992; Omichinski et al., 1993). Although dispensable for binding to the GATA-containing DNA motif, the N-ZnF contributes to stabilizing protein/DNA interaction, predominantly on palindromic GATA sequences (Yang and Evans, 1992; Trainor et al., 1996). In addition, it was shown that N-ZnF of GATA2 and GATA3 proteins can bind GATC-containing DNA motif, in a manner that depends on its adjacent basic region (Pedone et al., 1997). Finally, the GATA1 N-ZnF and C-ZnF domains participate in GATA factor’s interactions with other transcriptional regulators (Lowry and Mackay, 2006; DeVilbiss et al., 2016).
- (1) GATA1, (Xp11.23) Erythroid transcription factor
https://www.genecards.org/Search/Keyword?queryString=GATA1
GATA-Binding Factor 1 3 4
GF-1 3 4
GATA-Binding Protein 1 (Globin Transcription Factor 1) 2
Erythroid Transcription Factor 1 3
Transcription Factor GATA1 3
HAEADA 3
XLANP 3
XLTDA 3
Eryf1 4
XLTT 3
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This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]
GATA1 (GATA Binding Protein 1) is a Protein Coding gene. Diseases associated with GATA1 include Thrombocytopenia With Beta-Thalassemia, X-Linked and Thrombocytopenia, X-Linked, With Or Without Dyserythropoietic Anemia. Among its related pathways are Gene expression (Transcription) and Assembly of the pre-replicative complex. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is GATA2.
Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). ( GATA1_HUMAN,P15976 )
- Quaternary structure: May form homodimers or heterodimers with other isoforms.
- Interacts (via the N-terminal zinc finger) with ZFPM1.
Interacts with GFI1B.
Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner.
Interacts with LMCD1.
Interacts with BRD3 (By similarity).
Interacts with CREBBP; the interaction stimulates acetylation and transcriptional activity in vivo (By similarity).
Interacts with EP300.
Interacts with MED1, CCAR1 and CALCOCO1.
Interacts with CEBPE (PubMed:26019275).
- Interacts (via the N-terminal zinc finger) with ZFPM1.
(2) GATA2 (3q21.3),
Endothelial transcription factor GATA-2
Aliases: GeneCards Symbol:
GATA2
2
GATA Binding Protein 2
2
3
5
NFE1B
2
3
5
Endothelial Transcription Factor GATA-2
3
4
GATA-Binding Protein 2
2
4
MONOMAC
3
IMD21
3 Immunodeficiency 21
DCML 3
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA2&keywords=GATA2
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This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
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GATA2 is a transcription factor involved in stem cell maintenance with key roles in hematopoietic development. GATA2 mutations are associated with a variety of inherited and acquired immune disorders including myelodysplastic syndrome and acute myeloid leukemia. In addition to a role in hematopoiesis, the maintenance GATA2 expression has been implicated as a requirement in KRAS-driven non-small cell lung cancer. Preclinical models have indicated therapeutic benefit from targeting GATA2-mediated pathways in the context of KRAS-driven NSCLC.
Protein attributes for GATA2 GeneSize:480 amino acid, Quaternary structure:
- Interacts with BRD3 (By similarity).
Interacts with AR and CCAR1.
Interacts with MDFIC (By similarity).
- Interacts with BRD3 (By similarity).
GATA2 (GATA Binding Protein 2) is a Protein Coding gene. Diseases associated with GATA2 include Immunodeficiency 21 and Myelodysplastic Syndrome. Among its related pathways are Gene expression (Transcription) and Assembly of the pre-replicative complex. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is GATA3.
(3) GATA3 (10p14),
Trans-Acting T-Cell-Specific Transcription Factor GATA-3
Aliases for GATA3 Gene, GeneCards Symbol: GATA3 2
GATA Binding Protein 3 2 3 5HDR 2 3 5
Trans-Acting T-Cell-Specific Transcription Factor GATA-3 3 4
GATA-Binding Factor 3 3 4
GATA-Binding Protein 3 2
HDRS 3
( gen.cause of Hypoparathyroidism with sensorineural Deafness and Renal Dysplasia).
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA3&keywords=GATA3ns-acting
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This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
GATA3 (GATA Binding Protein 3) is a Protein Coding gene. Diseases associated with GATA3 include Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Syndrome and Hypoparathyroidism-Deafness-Renal Disease Syndrome. Among its related pathways are Gene expression (Transcription) and ESR-mediated signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is GATA2.
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. ( GATA3_HUMAN,P23771 )
- Quaternary structure: Interacts with TBX21 ('Tyr-530' phosphorylated form).
- ( SIVULÖYTÖ! GATA3;n interaktioproteiinista: https://www.genecards.org/cgi-bin/carddisp.pl?gene=TBX21&keywords=TBX21
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This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
(4) GATA4 (8p23.1),
Transcription Factor GATA-4,
GATA Binding Protein 4 2 3 5
Transcription Factor GATA-4 3 4
GATA-Binding Factor 4 3 4 GATA-Binding Protein 4 2
TACHD 3
ASD2 3
VSD1 3
TOF 3
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA4&keywords=GATA4
-
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] GeneCards Summary for GATA4 Gene. GATA4 (GATA Binding Protein 4) is a Protein Coding gene. Diseases associated with GATA4 include Testicular Anomalies With Or Without Congenital Heart Disease and Atrial Septal Defect 2. Among its related pathways are Gene expression (Transcription) and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is GATA6.
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, 27984724, 35182466). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735). ( GATA4_HUMAN,P43694 )https://pubmed.ncbi.nlm.nih.gov/15734735/
(5) GATA5,(20q13.33),
Transcription Factor GATA-5, CHTD5.
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA5&keywords=GATA5
(6) GATA6, (18q11.2)
Transcription Factor GATA-6
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA6&keywords=GATA6
(7) MTA1 (14q37.39)
Metastasis-associated protein MTA1
https://www.genecards.org/Search/Keyword?queryString=MTA1
NM_004689.4 → NP_004680.2 metastasis-associated protein MTA1 isoform MTA1.
Normaalisti TRIM25 ubikitinoi maksassa MTA1:n lysiiniin K98 ja johtaa degradaatioon.
Zf-GATA domeenien lisäksi tässä proteiinissa on DNA:ta sitovia domeeneja SANT SWI2, ADA2, N-CoR ja TFIIIB. ja BROMO adjacent Homolog domain BAH.
(8) MTA2 , (11q12.3)
P53 Target Protein In Deacetylase Complex 3 4
Metastasis-Associated Protein MTA2 3 4
Metastasis-Associated 1-Like 1 3 4
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MTA2&keywords=GATAD2A
(9) GATAD2B, (1q21.3)
Transcriptional repressor p66-beta
GATA zinc finger domain containin 2B, p68, MRD18, p68beta.
https://www.ncbi.nlm.nih.gov/gene/57459
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATAD2B&keywords=GATAD2B
(10) GATAD2A (19p13.11),
Transcriptional repressor p66-alpha.
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATAD2A&keywords=GATAD2A
GATA Zn finger domain containing 2A. ( Nutritional optic atrophy)
( 11) TRPS1 ( 23.3)
Transcriptional repressor GATA binding 1, GC79, LGCR)
Tricho-Rhino-Phalangeal Syndrome Type I Protein 3 4
Zinc Finger Transcription Factor Trps1 3 4
Trichorhinophalangeal Syndrome I 2 3
Zinc Finger Protein GC79 3 4 GC79 3
LGCR 3
- Q9UHF7
- Conserved Domains (2) summary
-
- smart00401
Location:897 → 940 . ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
- cd00202
Location:901 → 957. ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C -
- smart00401
-
Aliases for GATAD1 Gene
- 24.5. 2020. Muistiin näitä GATA- sinkkisormi - proteiineja ja transkriptiotekijöitä. löydän niitä vain 12, vaikka pitäisi löytää 15 vähintäin. Tuonkin TRPS1 löysin sattumalta, kun luin niistä proteiineista jotka ovat SARS2- mikroRNA- kohdeproteiineiksi oletettuja. Lisään listaa kun löydän GATAD Znf ryhmää.
- 7.12. 2023 tarkistan GATAD znf geenit, koska luen parhaillaan rintasyövätn immunohistokemiallisista merkitsijägeeneistä ja proteiineista. ja GATAD3 on mainittu.
- Teksti säästetty tietokoneelleni Znf proteiinit, Onkologia: znf sinkkipåroteiineja, Rintasyöpää koskevaa, GATAD znf proteiinit otsikoilla oleviin mappeihin
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