LOCUS NP_001012333 143 aa linear PRI 03-OCT-2017
DEFINITION midkine isoform a precursor [Homo sapiens].
ACCESSION NP_001012333
VERSION NP_001012333.1
DBSOURCE REFSEQ: accession NM_001012333.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 143)
AUTHORS Muramatsu T.
TITLE Midkine, a heparin-binding cytokine with multiple roles in
development, repair and diseases
JOURNAL Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. 86 (4), 410-425 (2010)
PUBMED 20431264
REMARK Review article
REFERENCE 2 (residues 1 to 143)
AUTHORS Tao P, Xu D, Lin S, Ouyang GL, Chang Y, Chen Q, Yuan Y, Zhuo X, Luo
Q, Li J, Li B, Ruan L, Li Q and Li Z.
TITLE Abnormal expression, highly efficient detection and novel
truncations of midkine in human tumors, cancers and cell lines
JOURNAL Cancer Lett. 253 (1), 60-67 (2007)
PUBMED 17379400
REFERENCE 3 (residues 1 to 143)
AUTHORS Iwasaki W, Nagata K, Hatanaka H, Inui T, Kimura T, Muramatsu T,
Yoshida K, Tasumi M and Inagaki F.
TITLE Solution structure of midkine, a new heparin-binding growth factor
JOURNAL EMBO J. 16 (23), 6936-6946 (1997)
PUBMED 9384573
REFERENCE 4 (residues 1 to 143)
AUTHORS Novotny WF, Maffi T, Mehta RL and Milner PG.
TITLE Identification of novel heparin-releasable proteins, as well as the
cytokines midkine and pleiotrophin, in human postheparin plasma
JOURNAL Arterioscler. Thromb. 13 (12), 1798-1805 (1993)
PUBMED 8241100
REFERENCE 5 (residues 1 to 143)
AUTHORS Kaname T, Kuwano A, Murano I, Uehara K, Muramatsu T and Kajii T.
TITLE Midkine gene (MDK), a gene for prenatal differentiation and
neuroregulation, maps to band 11p11.2 by fluorescence in situ
hybridization
JOURNAL Genomics 17 (2), 514-515 (1993)
PUBMED 8406506
REFERENCE 6 (residues 1 to 143)
AUTHORS Fairhurst JL, Kretschmer PJ, Kovacs E, Bohlen P and Kovesdi I.
TITLE Structure of the gene coding for the human retinoic acid-inducible
factor, MK
JOURNAL DNA Cell Biol. 12 (2), 139-147 (1993)
PUBMED 8471163
REFERENCE 7 (residues 1 to 143)
AUTHORS Uehara K, Matsubara S, Kadomatsu K, Tsutsui J and Muramatsu T.
TITLE Genomic structure of human midkine (MK), a retinoic acid-responsive
growth/differentiation factor
JOURNAL J. Biochem. 111 (5), 563-567 (1992)
PUBMED 1639750
REFERENCE 8 (residues 1 to 143)
AUTHORS Shoyab M, McDonald VL, Dick K, Modrell B, Malik N and Plowman GD.
TITLE Amphiregulin-associated protein: complete amino acid sequence of a
protein produced by the
12-0-tetradecanoylphorbol-13-acetate-treated human breast
adenocarcinoma cell line MCF-7
JOURNAL Biochem. Biophys. Res. Commun. 179 (1), 572-578 (1991)
PUBMED 1883381
REFERENCE 9 (residues 1 to 143)
AUTHORS Tsutsui J, Uehara K, Kadomatsu K, Matsubara S and Muramatsu T.
TITLE A new family of heparin-binding factors: strong conservation of
midkine (MK) sequences between the human and the mouse
JOURNAL Biochem. Biophys. Res. Commun. 176 (2), 792-797 (1991)
PUBMED 2025291
REFERENCE 10 (residues 1 to 143)
AUTHORS Kretschmer PJ, Fairhurst JL, Decker MM, Chan CP, Gluzman Y, Bohlen
P and Kovesdi I.
TITLE Cloning, characterization and developmental regulation of two
members of a novel human gene family of neurite outgrowth-promoting
proteins
JOURNAL Growth Factors 5 (2), 99-114 (1991)
PUBMED 1768439
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BI915189.1, BM016739.1,
BC011704.2 and AI494596.1.
Summary: This gene encodes a member of a small family of secreted
growth factors that binds heparin and responds to retinoic acid.
The encoded protein promotes cell growth, migration, and
angiogenesis, in particular during tumorigenesis. This gene has
been targeted as a therapeutic for a variety of different
disorders. Alternatively spliced transcript variants encoding
multiple isoforms have been observed. [provided by RefSeq, Jul
2012].
Transcript Variant: This variant (2) differs in the 5' UTR,
compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same
isoform (a).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: CN266447.1, BM016739.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1968189, SAMEA1968540
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..143
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p11.2"
Protein 1..143
/product="midkine isoform a precursor"
/note="amphiregulin-associated protein; midgestation and
kidney protein; neurite outgrowth-promoting factor 2;
retinoic acid inducible factor; neurite growth-promoting
factor 2"
/calculated_mol_wt=13421
sig_peptide 1..20
/experiment="experimental evidence, no additional details
recorded"
/note="{ECO:0000269|PubMed:15340161,
ECO:0000269|PubMed:1883381, ECO:0000269|PubMed:8241100};
propagated from UniProtKB/Swiss-Prot (P21741.1)"
/calculated_mol_wt=2183
mat_peptide 21..143
/product="Midkine"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P21741.1)"
/calculated_mol_wt=13421
Region 37..116
/region_name="PTN"
/note="Pleiotrophin / midkine family; smart00193"
/db_xref="CDD:128490"
CDS 1..143
/gene="MDK"
/gene_synonym="ARAP; MK; NEGF2"
/coded_by="NM_001012333.2:177..608"
/note="isoform a precursor is encoded by transcript
variant 2"
/db_xref="CCDS:CCDS7919.1"
/db_xref="GeneID:4192"
/db_xref="HGNC:HGNC:6972"
/db_xref="MIM:162096"
ORIGIN
1 mqhrgflllt llallaltsa vakkkdkvkk ggpgsecaew awgpctpssk dcgvgfregt
61 cgaqtqrirc rvpcnwkkef gadckykfen wgacdggtgt kvrqgtlkka rynaqcqeti
121 rvtkpctpkt kakakakkgk gkd
//
