https://www.genecards.org/cgi-bin/carddisp.pl?gene=CD38&keywords=cd38
Aliases for CD38 Gene
- GeneCards Symbol: CD38 2
- CD38 Molecule 2 3 5
- ADP-Ribosyl Cyclase 1 2 3 4
- CADPR1 2 3 5
- ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1 3 4
- 2'-Phospho-Cyclic-ADP-Ribose Transferase 3 4
- 2'-Phospho-ADP-Ribosyl Cyclase 3 4
- Cyclic ADP-Ribose Hydrolase 1 3 4
- NAD(+) Nucleosidase 2 3
- CD38 Antigen (P45) 2 3
- ADPRC 1 3 4
NCBI Gene Summary for CD38 Gene
-
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
GeneCards Summary for CD38 Gene
CD38 (CD38 Molecule) is a Protein Coding gene. Diseases associated with CD38 include Prolymphocytic Leukemia and Leukemia, Chronic Lymphocytic 2. Among its related pathways are NAD metabolism and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include transferase activity and hydrolase activity, acting on glycosyl bonds. An important paralog of this gene is BST1.
UniProtKB/Swiss-Prot Summary for CD38 Gene
Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion (PubMed:8253715, 7961800). Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid.
At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+) (PubMed:16690024). Has cADPR hydrolase activity (PubMed:8253715, 7961800). ( CD38_HUMAN,P28907 )
