ESCRT-III, CHMP1B (Kr.18p11.21) . Vps46B, C18-ORF2,CHMP1.5, hVps46-2

CHMP1B (Kr. 18p11.21)

https://www.ncbi.nlm.nih.gov/gene/57132

Preferred Names

charged multivesicular body protein 1b

Names

chromatin modifying protein 1B

chromatin-modifying protein 1b

vacuolar protein sorting 46-2

vacuolar protein sorting-associated protein 46-2

Vps46B; C10orf2; C18orf2; CHMP1.5; Vps46-2; C18-ORF2; hVps46-2

Summary  CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008] 

 

 RAKENNE: 

https://www.ncbi.nlm.nih.gov/protein/NP_065145.2